Results 51 to 60 of about 3,870,583 (322)

Interleukin‐13: prospects for new treatments [PDF]

Clinical & Experimental Allergy, 2009
SummaryIL‐13 is a T‐helper type 2 cytokine. Animal models have implicated IL‐13 as a critical cytokine in the development of asthma and chronic obstructive pulmonary disease (COPD). In vitro IL‐13 exerts important effects on both structural and inflammatory cells within the airway and has the capacity to drive the clinical features of airways disease ...
Brightling, CE, Saha, S, Hollins, F
openaire   +3 more sources

Potential Risks Related to Modulating Interleukin-13 and Interleukin-4 Signalling: A Systematic Review

Drug Safety, 2018
IntroductionInterleukin-13 and interleukin-4 are type-II cytokines signalling through the shared type II interleukin-4 receptor. As a result of their structural similarity, interleukin-13 and interleukin-4 have overlapping functions in the mediation of ...
M. Braddock, N. Hanania, A. Sharafkhaneh, G. Colice, M. Carlsson   +4 more
semanticscholar   +1 more source

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13

Brazilian Journal of Infectious Diseases
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B Coêlho, Maria Jania Teixeira, Erika Freitas Mota, Mércia Sindeaux Frutuoso, João Santana da Silva, Aldina Barral, Manoel Barral-Netto, Margarida Maria L Pompeu   +7 more
doaj   +1 more source

Tricellulin is regulated via interleukin 13 receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

Mucosal Immunology, 2017
In the two inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD), altered expression of tight junction (TJ) proteins leads to an impaired epithelial barrier including increased uptake of luminal antigens supporting the ...
S. M. Krug, C. Bojarski, A. Fromm, I. M. Lee, P. Dames, J. Richter, Turner, M. Fromm, J. Schulzke   +8 more
semanticscholar   +1 more source

The evaluation of interleukin-4 and interleukin-13 in the serum of pulmonary sarcoidosis and tuberculosis patients

Journal of Research in Medical Sciences, 2020
Background: Sarcoidosis and tuberculosis (TB) are two granulomatous inflammatory diseases with several common symptoms. The aim of the present study was to compare the serum levels of biomarkers including interleukin-4 (IL-4) and IL-13, calcium (Ca ...
Atefeh Abedini, Zohre Naderi, Arda Kiani, Majid Marjani, Esmaeil Mortaz, Fariba Ghorbani   +5 more
doaj   +1 more source

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

Nature Communications, 2017
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic ...
J. Newman, G. Wang, K. Arima, S. P. Guan, M. Waters, W. Cavenee, E. Pan, E. Aliwarga, S. Chong, Catherine Y L Kok, B. Endaya, A. Habib, T. Horibe, W. Ng, I. Ho, K. Hui, T. Kordula, P. Lam   +17 more
semanticscholar   +1 more source

Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis

Frontiers in Immunology, 2021
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that affects people of all ages. It is characterized by chronic eczema, constant pruritus, and severe discomfort. AD often progresses from mild annoyance to intractable
Jianghui Meng, Jianghui Meng, Yanqing Li, Michael J. M. Fischer, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Weiwei Chen, Jiafu Wang, Jiafu Wang   +12 more
doaj   +1 more source

MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1

Genes, 2018
Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functions in epithelium and has been linked to asthma, atopic dermatitis and ulcerative colitis (UC). Interleukin-13 signals through IL-13 receptor α-1 (IL13RA1
Markus Gwiggner, R. Martinez-Nunez, S. Whiteoak, Victor P Bondanese, A. Claridge, J. Collins, J. Cummings, T. Sanchez-Elsner   +7 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source