Results 81 to 90 of about 576,830 (304)
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]
, 1998 Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E. +6 more
core +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
Progress in the application of dupilumab for non-atopic dermatitis
Pifu-xingbing zhenliaoxue zazhiDupilumab inhibits Th2-mediated inflammatory responses by specifically blocking the signaling pathways of interleukin-4 and interleukin-13. Recently, in addition to its approved indication for the treatment of moderate-to-severe atopic dermatitis ...
SHI Xiwu +4 more
doaj +1 more source
Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht +6 more
core +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts
Allergology International, 2001 Background: Interleukin (IL)-4 and IL-13, which play a role in the production of allergic inflammation, can activate fibroblasts to elicit a variety of cellular functions.
Tatsuya Machino +5 more
doaj +1 more source
Construction of a knockout targeting vector to generate an Interleukin-13 Receptor α1 deficient Balb/c mouse [PDF]
, 2005 only availableA recent publication from our lab has provided evidence for the involvement of the α1 chain of the Interleukin-13 cytokine receptor (IL-13Rα1) in the development of the neonatal immune system.
Bautista, Roderick +2 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome
Folia Histochemica et Cytobiologica, 2010 Cytokines participate in many physiological processes including the regulation of immune and inflammatoryresponses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased .
Joanna Smigielska- Kuzia +5 more
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