Results 41 to 50 of about 5,584 (128)

Therapeutic Controlled Release Strategies for Human Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 2, January 14, 2025.
Therapeutic controlled release is a promising approach to treat the progressive and irreversible pathological changes in human osteoarthritis. This strategy is based on the application of recombinant molecules, drugs, and gene sequences via biocompatible materials and may provide effective and long‐lasting tools promoting the spatiotemporal delivery ...
Dan Wang, Wei Liu, Jagadeesh K. Venkatesan, Henning Madry, Magali Cucchiarini   +4 more
wiley   +1 more source

MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis [PDF]

, 2018
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. MiR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune ...
Barbara Tolusso, Charles McSharry, Elisa Gremese, Gianfranco Ferraccioli, Iain B. McInnes, Iain B. McInnes, Mariola Kurowska-Stolarska, Mariola Kurowska-Stolarska, Stefano Alivernini   +8 more
core   +2 more sources

Fibrosis‐Encapsulated Tumoroid, A Solid Cancer Assembloid Model for Cancer Research and Drug Screening

Advanced Healthcare Materials, Volume 13, Issue 31, December 16, 2024.
The Multi‐Layer Spheroid (MLS) formation method can construct Fibrosis‐Encapsulated Tumoroids (FETs), which replicate the structural characteristics of peritumoral fibrosis, serving as a tissue‐level simulator for cancer research and drug evaluation in solid tumors.
Yeonsue Jang, Suki Kang, Hyunho Han, Chang Moo Kang, Nam Hoon Cho, Baek Gil Kim   +5 more
wiley   +1 more source

The extracellular matrix and insulin resistance [PDF]

, 2015
The extracellular matrix (ECM) is a highly dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggest that ECM remodeling is associated with diet-induced insulin ...
Ashley S. Williams, Bataller, Berria, Bertola, Bisht, Bisht, Bisht, Bonner, Bonner, Brew, Carmiel-Haggai, Catalan, Catalan, Chajara, Cheung, Cheung, Dasu, David H. Wasserman, Day, Delcommenne, Demeulemeester, Derosa, Dixon, Duckworth, Duckworth, El Annabi, Eng, Farrell, Field, Friedman, Friedman, Gardner, Gheyara, Gkretsi, Gressner, Groh, Gullberg, Halberg, Hanks, Harrison, Hill, Hong, Hopps, Huang, Huang, Huber, Hynes, Hynes, Ilic, Inoue, Irwin, Jansson, Jaskiewicz, Jaworski, Jiang, Kang, Kang, Kang, Keophiphath, Khan, Kodama, Kodama, Lewis, Li Kang, Madison, Maher, Martinez-Hernandez, McCuskey, Menghini, Menghini, Moser, Pasarica, Persad, Plows, Postic, Pozzi, Qian, Richardson, Sakai, Schlaepfer, Schuppan, Signorelli, Solomon, Sun, Sun, Tam, Thrailkill, Tinahones, Toole, Troussard, Varma, Vaynberg, Volpes, Wada, Wang, Wang, Watts, White, Williams, Yadav, Zamurs, Zhang, Zong   +102 more
core   +2 more sources

Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies

Developmental Psychobiology, Volume 66, Issue 7, November 2024.
ABSTRACT Recent research has highlighted cerebellar involvement in cognition and several psychiatric conditions such as mood and anxiety disorders and schizophrenia. Attention‐deficit/hyperactivity disorder and autism spectrum disorder have been linked to reduced cerebellar volume as well.
Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs   +4 more
wiley   +1 more source

Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]

, 2017
Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet, Bayir, Hulya, Liu, Bing, Oltvai, Zoltan N, Pak, Stephen C, Perlmutter, David H, Silverman, Gary A   +6 more
core   +3 more sources

Differential analysis of genome-wide methylation and gene expression in mesenchymal stemcells of patients with fractures and osteoarthritis [PDF]

, 2016
Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the precursors of osteoblasts, may be compromised in elderly individuals,
Agustín F. Fernández, Alvaro del Real, Carmen G. Ibarbia, Carolina Sañudo, Flor M. Pérez-Campo, Jose A. Riancho, Maarten Braspenning, Mario F. Fraga, María A. Alonso, María I. Pérez-Núñez, Wim Van Criekinge, Xu J   +11 more
core   +2 more sources

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies [PDF]

, 2017
BACKGROUND: Mutations in the gene encoding thymidine kinase 2 (TK2) result in the myopathic form of mitochondrial DNA depletion syndrome which is a mitochondrial encephalomyopathy presenting in children. In order to unveil some of the mechanisms involved
Artuch Iriberri, Rafael, Colomer Oferil, Jaume, De Meirleir, Linda, De Paepe, Boel, Fagiolari, Gigliola, Ferrer, Isidro (Ferrer Abizanda), Jekovec-Vrhovsek, Maja, Jiménez Mallebrera, Cecilia, Jou, Cristina, Kalko, Susana, López Gallardo, Ester, Meznaric, Marija, Moggio, Maurizio, Montero Sánchez, Raquel, Montoya, Julio, Munell Casadesús, Francina, Nascimento, Andrés, Ortez, Carlos Ignacio, Paco Mercader, Sonia, Rodríguez, María Angeles, Rogac, Mihael, Roig Quilis, Manuel, Ruiz Pesini, Eduardo, Sciacco, Monica, Torner Rubies, Ferran   +24 more
core   +1 more source

The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis [PDF]

, 2016
The proinflammatory cytokine IL-18 has central anorexigenic effects and was proposed to contribute to loss of appetite observed during sickness. Here we tested in the mouse the hypothesis that IL-18 can decrease food intake by acting on neurons of the ...
Alboni, Silvia, Benatti, Cristina, Berton, Fulvia, Conti, Bruno, Francesconi, Walter, Mori, Simone, Moroncini, Gianluca, Nguyen, William, S\ue1nchez Alavez, Manuel, Tascedda, Fabio, Zorrilla, Eric   +10 more
core   +1 more source

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice [PDF]

, 2018
Background: Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops.
A Furby, A Kleinridders, A Tups, Aifric Muller, Alexander Tups, Amanda C. Morris, B Teusink, Baukje de Roos, Begona Porteiro, C Baker, C Koch, Carlos Dieguez, CE Koch, Christiane Koch, Christine Grant, CL Lyons, Claus-Dieter Mayer, CR Abraham, D Cai, D Cai, D Titolo, Darcy Kahn, Domenico Sergi, Eva-Maria Bachmair, F Licastro, F Sardi, Fiona C. McGillicuddy, Fiona H. McLean, Fiona M. Campbell, G Paxinos, G Tuncman, G Van Dijk, G Zhang, GN Luheshi, Helen M. Roche, I Dickson, J Benzler, J Cichy, J Cichy, J Hirosumi, JA Luchsinger, Janice E. Drew, JG Bode, JG Kim, JL Halaas, JL Zamanian, JM Zigman, Jonas Benzler, JP Thaler, JP Thaler, K FLURKEY, KE Berkseth, L Kilpatrick, Laura J. Hardie, LB Buckman, LM Williams, Lynda M. Williams, M Baccini, M Milanski, M Tsuda, M Vijay-Kumar, Mark V. Boekschoten, Michael Muller, Nigel Hoggard, Phyllis Nicol, PJ Scarpace, PS Maclean, R Edgar, RE Mrak, Ruben Nogueiras, RW Jeffery, S Madsbad, S Rivest, S Takada, S Zhang, SE Mitchell, T Mann, U Machein, World Health Organisation, WV Brown, X Zhang, Y Gao   +81 more
core   +3 more sources