Results 31 to 40 of about 5,608 (125)

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients [PDF]

, 2010
Background TNFRSF11B computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy.
Ju X Huang, L Wang, Ming H Jiang
core   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K., Davies, C.R., Duffy, M.A., Ferrier, R.K., Gusterson, B.A., Heath, V.J., Morris, J.S., Sandilands, G.P., Stein, T., Weber-Hall, S.J.   +9 more
core  

Soyasaponin and vertical microbial transmission: Maternal effect on the intestinal development and health of early chicks

iMeta, Volume 4, Issue 4, August 2025.
This study investigates the vertical transmission of maternal microbiota in chickens and how it is modulated by maternal soyasaponin supplementation. Using a model spanning the reproductive tract, egg components, and developing chicks, we show that maternal gut and reproductive microbiota, including Bifidobacterium adolescentis (B.
Mingkun Gao, Shu Chen, Hao Fan, Peng Li, Aiqiao Liu, Dongli Li, Xiaomin Li, Yongfei Hu, Guofeng Han, Yuming Guo, Zengpeng Lv   +10 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis

iMeta, Volume 4, Issue 2, April 2025.
A 4‐month of time‐restricted feeding (TRF) intervention alleviated cognitive impairments in Alzheimer's disease (AD) patients, while a 3‐month TRF regimen improved spatial memory, reduced amyloid‐beta accumulation, and promoted microglial aggregation around plaques in AD mice. Antibiotic‐induced gut microbiota depletion partly abolished TRF's benefits.
Yihang Zhao, Mengzhen Jia, Chen Ding, Bingkun Bao, Hangqi Li, Jiabin Ma, Weixuan Dong, Rui Gao, Xuhui Chen, Jiao Chen, Xiaoshuang Dai, Yuanqiang Zou, Jun Hu, Lin Shi, Xuebo Liu, Zhigang Liu   +15 more
wiley   +1 more source

Cardiomyocyte engineering: The meeting point of transcription factors, signaling networks, metabolism and function

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract Direct cardiac reprogramming or transdifferentiation is a relatively new and promising area in regenerative therapy, cardiovascular disease modeling, and drug discovery. Effective reprogramming of fibroblasts is limited by their plasticity, that is, their ability to reprogram, and depends on solving several levels of tasks: inducing ...
Oksana O. Piven, Raminta Vaičiulevičiūtė, Eiva Bernotiene, Pawel Dobrzyn   +3 more
wiley   +1 more source

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation [PDF]

, 2013
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while ...
Ahmadian, An, Anthony, Arita, Arkan, Bain, Barnes, Barré, Bauwens, Berggreen, Bourron, Boyle, Boyle, Brooks, Buhl, Carey, Carling, Carling, Caton, Chakrabarti, Chaves, Chavez, Chen, Chen, Cheung, Cinti, Cool, Coppari, Daval, Daval, Ducharme, Duncan, Dzamko, Egan, Emerling, Eringa, Fazakerley, Fischer, Fisher, Flechtner-Mors, Foretz, Fox, Fryer, Gaidhu, Gaidhu, Gaidhu, Gaidhu, Galic, Garton, Gauthier, Gauthier, Geraghty, Giri, Glass, Grimaldi, Guigas, Gurriarán-Rodríguez, Gustafson, Habinowski, Hardie, Hawley, Hawley, Hawley, Henin, Hevener, Holmes, Hutchinson, Huypens, Ian P. Salt, Iglesias, Imamura, Iwatsubo, Jeon, Jeong, Jiao, Kanda, Kelly, Kim, Kitade, Koh, Kohlstedt, Koistinen, Kola, Kou, Kramer, Kristensen, Lee, Lee, Li, Lihn, Lihn, Lin, Lin, Liu, Lorente-Cebrián, Luo, López, Lönnqvist, MacDougald, Martínez-Agustin, Marzolla, McBride, McGee, McInnes, McInnes, Minokoshi, Mulligan, Narkar, Nguyen, Nishimura, Nishimura, Odegaard, Ojuka, Ojuka, Orci, Pagnon, Park, Peng, Perrotti, Peyton, Polakof, Pulinilkunnil, Rasmussen, Reihill, Reshef, Reshef, Rosen, Saberi, Sag, Sakamoto, Sakamoto, Sakaue, Sakoda, Salt, Salt, Salt, Samovski, Sano, Sarah J. Mancini, Schwenk, Scott, Shi, Silvia Bijland, Solinas, Sponarova, Steinberg, Steinberg, Su, Sullivan, Sun, Takekoshi, Tam, Tang, Turer, Vandanmagsar, Vats, Vaughan, Vila-Bedmar, Villena, Vingtdeux, Viollet, Vucetic, Wan, Wang, Wang, Wang, Watt, Winder, Woods, Wu, Xiao, Xu, Yamauchi, Yang, Yin, Yuen, Zhang, Zhang, Zhang, Zhang, Zhou, Zimmermann, Zmijewski   +182 more
core   +1 more source

Therapeutic Controlled Release Strategies for Human Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 2, January 14, 2025.
Therapeutic controlled release is a promising approach to treat the progressive and irreversible pathological changes in human osteoarthritis. This strategy is based on the application of recombinant molecules, drugs, and gene sequences via biocompatible materials and may provide effective and long‐lasting tools promoting the spatiotemporal delivery ...
Dan Wang, Wei Liu, Jagadeesh K. Venkatesan, Henning Madry, Magali Cucchiarini   +4 more
wiley   +1 more source