Results 11 to 20 of about 5,608 (125)

Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring. [PDF]

J Neurochem
Maternal obesity during pregnancy induces metabolic and inflammatory disturbances that alter the offspring brain environment, characterized by neuroinflammation, glial activation, disrupted neurotransmitter signaling, and mitochondrial and synaptic dysfunction, ultimately increasing the risk of adverse neurodevelopmental outcomes, with persistent ...
Schmitt LO, Faraco G, Stivanin TS, Gaspar JM.   +3 more
europepmc   +2 more sources

Uncovering the role of genetic polymorphisms in cervical insufficiency. [PDF]

Int J Gynaecol Obstet
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kalinderi K, Kalinderis M, Chatzidimitriou M, Fidani L.   +3 more
europepmc   +2 more sources

Epilepsy: Molecular Pathogenesis and Emerging Therapies. [PDF]

MedComm (2020)
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Huang W, Zong J, Zhang Y, Li M, Pan S, Xiao Z.   +5 more
europepmc   +2 more sources

Biologics for the treatment of chronic rhinosinusitis with nasal polyps : state of the art [PDF]

, 2019
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex upper airway disease affecting up to 11% of the population of Western Europe. In these western countries, 85% of the CRSwNP disease reveals a type 2 inflammatory pattern. In the last 15 years,
Bachert, Claus, Ren, Lei, Zhang, Luo, Zhang, Nan   +3 more
core   +1 more source

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation [PDF]

, 2016
yesInflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance.
Alomar, Anna D. White, Bain, Benoit Viollet, Benziane, Bess, Bijland, Boyle, Brenner, Castanares-Zapatero, Chen, Claire Rutherford, Cohen, Coughlan, Delyth Graham, Dong, Erik A. Richter, Ewart, Flannery, Foretz, Fritzen, Galic, García-García, Gauthier, Green, Guigas, Göransson, Habinowski, Hawley, Ian P. Salt, Jeong, Jørgensen, Kim, Kim, Kwon, Laderoute, Lee, Lihn, Lihn, Lumeng, Meares, Miyokawa-Gorin, Moreno, Mottillo, Nerstedt, Qu, Rhian M. Touyz, Rios, Ross, Rotter, Rutherford, Sag, Salt, Sarah J. Mancini, Scott, Shibata, Silvia Bijland, Sun, Takahashi, Thiefes, Timothy M. Palmer, Viollet, Wang, Wang, Wang, Woods, Wu, Xu, Yang, Zaha, Zhang, Zhao   +71 more
core   +5 more sources

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly, Ballon, Bansal, Benians, Bernstein, Blanks, Brodt-Eppley, Chatterjee, Cho, De Vries, Dohlman, Druey, Europe-Finner, Georgoussi, Graham Ladds, Hague, Hao, Hepler, Hill, Hollinger, Hu, John Davey, Koelle, Ladds, Langer, Li, Lopez-Bernal, Manu Vatish, Milligan, Mittmann, Moore, Neitzel, O'Brien, Park, Phaneuf, Plested, Ross, Saitoh, Sanborn, Sevasti Zervou, Snabaitis, Snow, Steven Thornton, Suarez, Tamirisa, Tang, Tinker, Tribe, Wang, Willars, Xie, Xu, Zeng   +52 more
core   +1 more source

IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13 [PDF]

, 2008
Background: IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of ...
A Tomkinson, D Hebenstreit, D Kuperman, DA Kuperman, DS Faffe, DS Robinson, F Syed, G Grunig, G Grynkiewicz, GK Hershey, H Dickensheets, H Huang, H Ogata, HL Dickensheets, J Kellner, J Ohara, JA Losman, JC Laporte, K Espinosa, L Cohn, L Cohn, M Humbert, M Yoshida, MM Mentink-Kane, MO Daines, MO Daines, NM Heller, O Tliba, PE Moore, Q Chen, Q Peng, R Leigh, S Fichtner-Feigl, S Yamamoto, S Yasunaga, S Zuyderduyn, SA Shore, SJ Hirst, SO Rahaman, SP Hogan, SP Hogan, T Akimoto, T Naseer, T Sato, T Zheng, V Govindaraju, Z Huang, Z Zhu   +47 more
core   +4 more sources

The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes [PDF]

, 2014
Rationale: Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer.
Belloni, Paula, Bowler, Russell P, Carolan, Brendan J, Cockayne, Debra A, Comellas, Alejandro P, Han, Meilan, Hersh, Craig P, Hughes, Grant, Kechris, Katerina, Morrow, Jarrett, O’Neal, Wanda K, Pillai, Sreekumar G, Rennard, Stephen, Zemans, Rachel L   +13 more
core   +5 more sources

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity [PDF]

, 2016
Background: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease.
David J. Volsky, Evelyn Wesseling, Hendrikus W. Boddeke, Marco Matos, Paula Agostinho, Rodrigo A. Cunha, Sabita Roy, Santanu Banerjee, Shamsudheen Moidunny   +8 more
core   +13 more sources

Gram-positive pathogenic bacteria induce a common early response in human monocytes [PDF]

, 2010
Background We infected freshly isolated human peripheral monocytes with live bacteria of three clinically important gram-positive bacterial species, Staphylococcus aureus, Streptococcus pneumoniae and Listeria monocytogenes and studied the ensuing early ...
Svetlin Tchatalbachev, Rohit Ghai, Hamid Hossain, Trinad Chakraborty   +3 more
core   +2 more sources