Results 41 to 50 of about 6,030,964 (134)

Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory [PDF]

, 2010
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified.
Poole, A
core  

Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis

iMeta, Volume 4, Issue 2, April 2025.
A 4‐month of time‐restricted feeding (TRF) intervention alleviated cognitive impairments in Alzheimer's disease (AD) patients, while a 3‐month TRF regimen improved spatial memory, reduced amyloid‐beta accumulation, and promoted microglial aggregation around plaques in AD mice. Antibiotic‐induced gut microbiota depletion partly abolished TRF's benefits.
Yihang Zhao, Mengzhen Jia, Chen Ding, Bingkun Bao, Hangqi Li, Jiabin Ma, Weixuan Dong, Rui Gao, Xuhui Chen, Jiao Chen, Xiaoshuang Dai, Yuanqiang Zou, Jun Hu, Lin Shi, Xuebo Liu, Zhigang Liu   +15 more
wiley   +1 more source

Cardiomyocyte engineering: The meeting point of transcription factors, signaling networks, metabolism and function

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract Direct cardiac reprogramming or transdifferentiation is a relatively new and promising area in regenerative therapy, cardiovascular disease modeling, and drug discovery. Effective reprogramming of fibroblasts is limited by their plasticity, that is, their ability to reprogram, and depends on solving several levels of tasks: inducing ...
Oksana O. Piven, Raminta Vaičiulevičiūtė, Eiva Bernotiene, Pawel Dobrzyn   +3 more
wiley   +1 more source

Therapeutic Controlled Release Strategies for Human Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 2, January 14, 2025.
Therapeutic controlled release is a promising approach to treat the progressive and irreversible pathological changes in human osteoarthritis. This strategy is based on the application of recombinant molecules, drugs, and gene sequences via biocompatible materials and may provide effective and long‐lasting tools promoting the spatiotemporal delivery ...
Dan Wang, Wei Liu, Jagadeesh K. Venkatesan, Henning Madry, Magali Cucchiarini   +4 more
wiley   +1 more source

Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]

, 2002
Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core  

Biomarkers in Schizophrenia: Current Approaches and New Developments—A Literature Review

Behavioural Neurology, Volume 2025, Issue 1, 2025.
Schizophrenia (SZ) is categorized as a chronic severe highly heritable brain disease. Symptoms include positive, negative, and cognitive symptoms. Despite numerous theories concerning the etiopathogenesis of SZ, the symptoms, although characteristic in their phenomenology, manifest themselves in a rather heterogeneous manner, which makes them subject ...
Alicja Sierakowska, Ewa Niewiadomska, Sebastian Łabuda, Anna Bieniasiewicz, Mateusz Roszak, Beata Łabuz-Roszak, Enzo Emanuele   +6 more
wiley   +1 more source

Fibrosis‐Encapsulated Tumoroid, A Solid Cancer Assembloid Model for Cancer Research and Drug Screening

Advanced Healthcare Materials, Volume 13, Issue 31, December 16, 2024.
The Multi‐Layer Spheroid (MLS) formation method can construct Fibrosis‐Encapsulated Tumoroids (FETs), which replicate the structural characteristics of peritumoral fibrosis, serving as a tissue‐level simulator for cancer research and drug evaluation in solid tumors.
Yeonsue Jang, Suki Kang, Hyunho Han, Chang Moo Kang, Nam Hoon Cho, Baek Gil Kim   +5 more
wiley   +1 more source

Investigating the interplay between excitatory neurotransmission and GABAa receptor expression and trafficking in the stargazer mutant mouse [PDF]

, 2006
The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The stargazer mutation results in the complete ablation of expression of TARPy2， an AMPA receptor (AMPAR) auxiliary subunit.
Payne, Helen Louise
core  

Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies

Developmental Psychobiology, Volume 66, Issue 7, November 2024.
ABSTRACT Recent research has highlighted cerebellar involvement in cognition and several psychiatric conditions such as mood and anxiety disorders and schizophrenia. Attention‐deficit/hyperactivity disorder and autism spectrum disorder have been linked to reduced cerebellar volume as well.
Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs   +4 more
wiley   +1 more source

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham, Thornton, Steven, Zervou, Sevasti I., Vatish, Manu, Davey, John   +4 more
core   +1 more source