Results 101 to 110 of about 68,075,562 (146)
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Interleukin-17 as a key player in neuroimmunometabolism
Nature Metabolism, 2023In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression throughout evolution, dating as far back as cnidaria, molluscs and worms, which predate lymphocytes. The evolutionary conservation of IL-17 suggests that it is involved in innate defence strategies, but also ...
Aaron Douglas +2 more
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Regulation of Interleukin-17 Production
2016Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection ...
Wenjuan, Dong, Xiaojing, Ma
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Current Protocols in Immunology, 2001
AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
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AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
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Interleukin-17 and airway remodelling
Pulmonary Pharmacology & Therapeutics, 2006Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
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Interleukin-17 Antagonists in the Treatment of Psoriasis
Journal of Cutaneous Medicine and Surgery, 2015Background Psoriasis is a chronic, immune-mediated inflammatory skin disorder of unknown etiology. Interleukin (IL)-17a, a key product of the recently identified Th17 cell subset, has been found to play a critical role in the immunopathogenesis of psoriasis.
Shivani Felicia, Chandrakumar +1 more
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Interleukin-8 and Interleukin-17 for Cancer
Cancer Investigation, 2014Pro-inflammatory cytokines have been associated with chronic inflammation and inflammatory diseases. Increased levels of interleukins (ILs) have been associated with inflammatory disease exacerbation. ILs levels have been observed to be associated with advance stage cancer for several types of cancer and a poor prognostic maker for malignant disease ...
Paul, Zarogoulidis +5 more
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Interleukin-17: a mediator of inflammatory responses
Cellular and Molecular Life Sciences CMLS, 2004Interleukin-17 (IL-17) is a prototype member of a new cytokine family with six species identified to date. IL-17 is secreted mainly by activated CD4(+) and CD8(+) T lymphocytes, while its receptor is distributed ubiquitously. IL-17 has been classified as a proinflammatory cytokine because of its ability to induce the expression of many mediators of ...
J, Witowski, K, Książek, A, Jörres
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Molecular characterization of duck interleukin-17
Veterinary Immunology and Immunopathology, 2009Interleukin-17 (IL17), belonging to the Th17 family, is a proinflammatory cytokine produced by activated T cells. A 1034bp cDNA encoding duck IL17 (duIL17) was cloned from Con A-activated splenic lymphocytes of ducks. The encoded protein, which is predicted to consist of 169 amino acids, has a molecular weight of 18.8kDa and includes a 29 residue NH(2)-
Jeongmi, Yoo +7 more
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Psoriasis: rationale for targeting interleukin-17.
The British journal of dermatology, 2012The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and fungi.
GIROLOMONI, Giampiero +2 more
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Interleukin 17 is a chief orchestrator of immunity
Nature Immunology, 2017Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this cytokine is a central player in immunity at the sites most exposed to microorganisms. Although it has been strongly associated with immunopathology, IL-17 also has an important role in host defense.
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