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Interleukin-8 and Interleukin-17 for Cancer
Cancer Investigation, 2014Pro-inflammatory cytokines have been associated with chronic inflammation and inflammatory diseases. Increased levels of interleukins (ILs) have been associated with inflammatory disease exacerbation. ILs levels have been observed to be associated with advance stage cancer for several types of cancer and a poor prognostic maker for malignant disease ...
Paul, Zarogoulidis +5 more
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Molecular characterization of duck interleukin-17
Veterinary Immunology and Immunopathology, 2009Interleukin-17 (IL17), belonging to the Th17 family, is a proinflammatory cytokine produced by activated T cells. A 1034bp cDNA encoding duck IL17 (duIL17) was cloned from Con A-activated splenic lymphocytes of ducks. The encoded protein, which is predicted to consist of 169 amino acids, has a molecular weight of 18.8kDa and includes a 29 residue NH(2)-
Jeongmi, Yoo +7 more
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Interleukin-17 in post-stroke neurodegeneration
Neuroscience & Biobehavioral Reviews, 2013Stroke is a leading cause of physical disability with neurodegenerative sequelae such as dementia and depression causing significant excess morbidity. Stroke severity can be exacerbated by apoptotic cell death in ischemic tissue, of which inflammatory activity is a key determinant.
Walter, Swardfager +4 more
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Interleukin 17 is a chief orchestrator of immunity
Nature Immunology, 2017Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this cytokine is a central player in immunity at the sites most exposed to microorganisms. Although it has been strongly associated with immunopathology, IL-17 also has an important role in host defense.
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Psoriasis: rationale for targeting interleukin-17.
The British journal of dermatology, 2012The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and fungi.
GIROLOMONI, Giampiero +2 more
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Role of Interleukin-17 and the Neutrophil in Asthma
International Archives of Allergy and Immunology, 2001Recent clinical evidence shows that acute, severe exacerbations of asthma are associated with recruitment and activation of neutrophils in the airways. There is also experimental evidence from rodents that T-lymphocytes are involved in the recruitment of neutrophils following allergen challenge in sensitised airways. This review addresses the potential
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American Journal of Respiratory Cell and Molecular Biology, 2003
Jay K. Kolls +2 more
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Jay K. Kolls +2 more
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