Results 321 to 330 of about 3,298,250 (374)

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Leveraging Evolutionary Immunology in Interleukin-6 and Interleukin-17 Signaling for Lung Cancer Therapeutics. [PDF]

ACS Pharmacol Transl Sci
Khilwani R, Singh S.
europepmc   +1 more source

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease [PDF]

, 2019
Atkins, Annette R., Bapat, Sagar P., Burris, Thomas P., Chang, Christina, Cho, Han, Downes, Michael, Evans, Ronald M., Kamenecka, Theodore M., Leblanc, Mathias, Liang, Yuqiong, Loo, Chin-San, Solt, Laura A., Yu, Ruth T., Zhao, Xuan, Zheng, Ye   +14 more
core   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Ly6G⁺ Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by Plasmodium berghei ANKA. [PDF]

Research (Wash D C)
Su Z, Li Q, Zhang Y, Liu T, Lv K, Feng A, Yang Y, Zhang Y, Wei Z, Sang X, Feng Y, Chen R, Jiang N, Chen Q.   +13 more
europepmc   +1 more source

The Role of Interleukin 17 Cytokine in Asthma and Its Relation with Severity of Attack

Amjed H. Abbas, Ahmed Hussein Jasim, Samir Sawadi Hammoud, Hayder Abdul-Amir Makki Al-Hindy, Kareem Nasir Hussien Alesawi   +4 more
openalex   +2 more sources

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions. [PDF]

Nat Metab
Kao YS, Lauterbach M, Lopez Krol A, Distler U, Godoy GJ, Klein M, Argüello RJ, Boukhallouk F, Vallejo Fuente S, Braband KL, Nurbekova A, Romero M, Mamareli P, Silva L, Damasceno LEA, Rampoldi F, Berod L, Lynch L, Hiller K, Sparwasser T.   +19 more
europepmc   +1 more source

Clinical characterisation of super-responders and super-non-responders in psoriasis patients treated with interleukin-17 inhibitors: A real-world study

Lihong Zhang, Hanqing Geng, Wenchao Li, Hong Liu   +3 more
openalex   +1 more source

CD25 downregulation by tumor exosomal microRNA-15a promotes interleukin-17-producing γδ-T-cells-mediated radioresistance in nasopharyngeal carcinoma. [PDF]

MedComm (2020)
Wang X, Xiang Z, Zhang Y, Tu CR, Huang C, Chung Y, Zhang W, Wang M, Liu Y, Tu W.   +9 more
europepmc   +1 more source