Results 341 to 350 of about 3,298,250 (374)

Regulation of Interleukin-17 Production

2016
Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection ...
Wenjuan, Dong, Xiaojing, Ma
openaire   +2 more sources

Measurement of Interleukin 17

Current Protocols in Immunology, 2001
AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
openaire   +1 more source

Interleukin-17 and the interleukin-17 family member network.

Allergy and asthma proceedings, 2004
Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively.
HUANG SH, FRYDAS S, KEMPURAJ D, BARBACANE, Renato Carmine, GRILLI, Alfredo, BOUCHER W, LETOURNEAU R, MADHAPPAN B, PAPADOPOULOU N, VERNA, Nicola, DE LUTIIS, Maria Anna, IEZZI, Teresa, RICCIONI, Graziano, THEOHARIDES TC, CONTI, Pio   +14 more
openaire   +2 more sources

Interleukin-17 as a key player in neuroimmunometabolism

Nature Metabolism, 2023
A. Douglas, Brenneth Stevens, L. Lynch
semanticscholar   +1 more source

Interleukin-17 and airway remodelling

Pulmonary Pharmacology & Therapeutics, 2006
Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
openaire   +2 more sources

Interleukin-17 in post-stroke neurodegeneration

Neuroscience & Biobehavioral Reviews, 2013
Stroke is a leading cause of physical disability with neurodegenerative sequelae such as dementia and depression causing significant excess morbidity. Stroke severity can be exacerbated by apoptotic cell death in ischemic tissue, of which inflammatory activity is a key determinant.
Walter, Swardfager, Daniel A, Winer, Nathan, Herrmann, Shawn, Winer, Krista L, Lanctôt   +4 more
openaire   +2 more sources

Interleukin-17 in inflammatory skin disorders

Current Opinion in Allergy & Clinical Immunology, 2007
Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset.Th17 cells are involved in protection against bacterial ...
Astrid J, van Beelen, Marcel B M, Teunissen, Martien L, Kapsenberg, Esther C, de Jong   +3 more
openaire   +2 more sources

Interleukin-17 and fat: Timing is everything

Immunity
Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.
Matthew C. Sinton, Olivia Shorthouse, Alice Costain, Juan F. Quintana   +3 more
openaire   +2 more sources

Interleukin-17 and Kidney Allograft Outcome

Transplantation Proceedings, 2009
Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only
J C O, Crispim, R, Grespan, G, Martelli-Palomino, D M, Rassi, R S, Costa, L T, Saber, F Q, Cunha, E A, Donadi   +7 more
openaire   +2 more sources

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Nature Immunology, 2005
L. Harrington, R. D. Hatton, Paul R. Mangan, H. Turner, T. Murphy, K. Murphy, C. Weaver   +6 more
semanticscholar   +1 more source