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Psoriasis: rationale for targeting interleukin-17.
The British journal of dermatology, 2012The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and fungi.
GIROLOMONI, Giampiero +2 more
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Development, cytokine profile and function of human interleukin 17–producing helper T cells
Nature Immunology, 2007N. Wilson +15 more
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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Nature Immunology, 2007Eva Acosta-Rodriguez +7 more
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American Journal of Respiratory Cell and Molecular Biology, 2003
Jay K, Kolls +2 more
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Jay K, Kolls +2 more
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Interleukin 17 is a chief orchestrator of immunity
Nature Immunology, 2017M. Veldhoen
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