Results 71 to 80 of about 579,314 (305)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation

Scientific Reports, 2018
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas   +6 more
doaj   +1 more source

Evaluation of interleukin 17: A polymorphism in patients with visceralleishmaniasis [PDF]

Journal of Analytical Research in Clinical Medicine, 2014
Introduction: Visceral leishmaniasis (VL) is an infectious disease that it has spread in more than 60 countries, in Iran it is caused by Leishmania infantum.
Safar Sadighi, Ahad Bazmany, Zohreh Babaloo, Hamid Amadi   +3 more
doaj   +1 more source

Periodontal manifestations as related to the cytokines in the gingival crevicular fluid

Indian Journal of Dental Sciences, 2021
Backround: Periodontal diseases are classified into different categories based on the clinical symptoms and related to these there can be changes in the cytokine levels in the connective tissue and elaboration of these in the gingival crevicular fluid ...
Nymphea Pandit, Neeta Bhavsar
doaj   +1 more source

Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. [PDF]

, 2017
Granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by T helper 17 (Th17) cells plays an essential role in autoimmune diseases. Transcriptional regulation of Th17 cell differentiation has been extensively studied, but post-transcriptional ...
Adamiak, William, Atasoy, Ulus, Chen, Jing, Huang, Ganlei, Rostami, Abdolmohamad M., Yu, Shiguang   +5 more
core   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Evaluation of the efficacy and safety of an interleukin-17 inhibitor in hospitalized COVID-19 patients

Consilium Medicum
Aim. To evaluate the clinical efficacy and safety of netakimab (an interleukin-17 inhibitor) in hospitalized patients with severe COVID-19. Materials and methods. A retrospective case-control study was conducted involving 171 patients. The main group (
Zamira M. Merzhoeva, Andrey I. Yaroshetskiy, Natalya A. Tsareva, Natalia V. Trushenko, Galiya S. Nuralieva, Irina A. Mandel, Viliya V. Gaynitdinova, Sergey N. Avdeev   +7 more
doaj   +1 more source

Interleukin-17: Why the Worms Squirm [PDF]

Immunity, 2017
IL-17 is a cytokine known primarily for its role in inflammation. In a recent issue of Nature, Chen et al. (2017) demonstrate that IL-17 plays a neuromodulatory role in Caenorhabditis elegans by acting directly on neurons to amplify neuronal responses to stimuli and produce changes in animal behavior.
Silverstein, Noah J., Huh, Jun R.
openaire   +3 more sources

Identification of the salmonid IL-17A/F1a/b, IL-17A/F2b, IL-17A/F3 and IL-17N genes and analysis of their expression following in vitro stimulation and infection [PDF]

, 2015
Peer ...
Husain, Mansourah, Jiang, Yousheng, Secombes, Christopher J., Wang, Alex, Wang, Tiehui, Xu, Qiaoqing   +5 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source