Results 91 to 100 of about 46,140 (235)

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Md. Sakhawat Hossain, Sanzida Khatun, Md Mojnu Mia, Fatematuz Zohora, Md. Rifat Sarker, K. M. Tanjida Islam, Md. Abu Sayeed, Moushumi Afroza Mou, Sherif Hamidu, Fatima Hamidu, A. M. Wasaf Hasan, Sanjida Mumtaj, Md Khaled Hossain, Md Sohel   +13 more
wiley   +1 more source

The effect of high-intensity functional training with thylakoid supplementation on interleukins-1beta and interleukins 8 in obese men [PDF]

Journal of Medicinal Plants
Background: Obesity is a widespread public health concern with a growing global prevalence, leading to an increased risk of chronic metabolic conditions.
Heidar EbadiAsl, Bahman Mirzaei, Arsalan Damirchi   +2 more
doaj  

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. [PDF]

PLoS ONE, 2009
BACKGROUND:The type-1 cytokine pathway plays a pivotal role in immunity against intracellular bacterial pathogens such as Salmonellae and Mycobacteria. Bacterial stimulation of pattern recognition receptors on monocytes, macrophages and dendritic cells ...
Diederik van de Wetering, Roelof A de Paus, Jaap T van Dissel, Esther van de Vosse   +3 more
doaj   +1 more source

Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells [PDF]

Molecular Human Reproduction, 2003
In addition to prostaglandins, inflammatory cytokines induce uterine contraction via oxytocin (OT). Placental leucine aminopeptidase (P-LAP), an oxytocinase that is identical to cystine aminopeptidase, destroys OT activity. Patients with spontaneous preterm delivery have higher concentrations of inflammatory cytokines and lower P-LAP activities than ...
Yoko, Ikoma, Seiji, Nomura, Tomomi, Ito, Yoshinari, Katsumata, Masayuki, Nakata, Kumi, Iwanaga, Mayumi, Okada, Fumitaka, Kikkawa, Koji, Tamakoshi, Tetsuo, Nagasaka, Masafumi, Tsujimoto, Shigehiko, Mizutani   +11 more
openaire   +2 more sources

Value of nafamostat mesylate in venoarterial extracorporeal membrane oxygenation anticoagulation—A retrospective cross‐sectional study

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 6, December 2025.
Abstract Background Anticoagulation is a key measure during venoarterial extracorporeal membrane oxygenation (VA‐ECMO) maintenance therapy. Nafamostat mesylate (NM) has emerged as a potential alternative to heparin. We assessed the value of anticoagulation with NM during VA‐ECMO therapy.
Jianhua Wu, Fujin Chen, Yujie Pan, Jincun Shi, Tong Su, Bukao Ni, Dechang Chen, Xiaobo Wang   +7 more
wiley   +1 more source

How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta

, 2000
The overall structure of the transition state and intermediate ensembles experimentally observed for Dihydrofolate Reductase and Interleukin-1beta can be obtained utilizing simplified models which have almost no energetic frustration.
Alm, C. Clementi, Dill, Galzitskaya, Heidary, J. N. Onuchic, JONES, Jones, Jones, Klimov, Kuwajima, Leopold, Li, Mirny, Munoz, Nelson, Nymeyer, Onuchic, Onuchic, Onuchic, P. A. Jennings, Plaxco, Shea, Sobolev, Varley   +24 more
core   +2 more sources

Febrile seizures: mechanisms and relationship to epilepsy. [PDF]

, 2009
Studies of febrile seizures have been driven by two major enigmas: first, how these most common of human seizures are generated by fever has not been known.
Alheim, Amy L. Brewster, Annegers, Annegers, Aram, Audenaert, Balestrino, Ban, Baram, Baram, Barone, Bender, Bender, Berg, Berg, Berg, Berg, Berg, Brewster, Brewster, Cartmell, Cartmell, Cendes, Chang, Chen, Chen, Chen, Céline M. Dubé, Dubé, Dubé, Dubé, Dubé, Dzhala, Escayg, French, Fukuda, Gatti, Germano, Hamati-Haddad, Harkin, Haspolat, Heida, Heida, Holtzman, Ichiyama, Isaac, Jiang, Kamal, Kang, Lahat, Le Van Quyen, Lemmens, Morimoto, Morimoto, Moser, Nelson, Pellegrini-Giampietro, Provenzale, Racine, Raspall-Chaure, Richichi, Sanchez, Scantlebury, Schuchmann, Shibasaki, Shinnar, Stafstrom, Takao, Tallie Z. Baram, Tan, Theodore, Toth, Tütüncüoğlu, Verity, Verity, Verity, Vezzani, Virta, Wallace, Zerr   +79 more
core   +1 more source

Exploiting glial cell functions for neurodegeneration therapy

Neuroprotection, Volume 3, Issue 4, Page 353-357, December 2025.
The figure illustrates the potential of targeting glial cell functions and their interactions with neurons as a therapeutic strategy for neurodegeneration. Abstract Glial cells, alongside neurons, are the major cells of the central nervous system.
Tobiloba S. Olajide
wiley   +1 more source

Minoxidil Promotes Hair Growth in a Mouse Model of Telogen Effluvium Induced by Lipopolysaccharide

The Journal of Dermatology, Volume 52, Issue 12, Page 1864-1868, December 2025.
ABSTRACT Telogen effluvium (TE) refers to a transient hair loss condition due to the global and premature transition of scalp hair follicles from the anagen to the telogen phase of the hair cycle leading to excessive hair loss, which is triggered by a variety of physical/emotional stress, including severe infectious diseases.
Yuji Tani, Shiro Makihara, Akihisa Morito, Manabu Ohyama   +3 more
wiley   +1 more source

Ausência de associação entre polimorfismo do gene da interleucina-1 beta e o prognóstico de pacientes com traumatismo crânio-encefálico grave Lack of association between interleukin-1 gene polymorphism and prognosis in severe traumatic brain injury patients

Revista Brasileira de Terapia Intensiva, 2009
OBJETIVO: O traumatismo crânio-encefálico é a principal causa de óbito em indivíduos com idade entre 1 a 45 anos. O desfecho do traumatismo crânio-encefálico pode estar relacionado, além de fatores pré-morbidade e gravidade do dano, com fatores genéticos.
Taís Frederes Krämer Alcalde, Andrea Regner, Edison Moraes Rodrigues Filho, Patrícia Corso Silveira, Gabriela Gonçalves Grossi, Daniel Simon   +5 more
doaj   +1 more source