Results 81 to 90 of about 242,716 (208)

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat, Heiko Mühl, Malte Bachmann, Josef Pfeilschifter, Pfeilschifter, Josef, Bachmann, Malte, Mühl, Heiko, Paulukat, Jens   +7 more
core   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II

Clinical and Experimental Pharmacology and Physiology, Volume 53, Issue 8, August 2026.
ABSTRACT Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)‐mediated cardiac hypertrophy pathogenesis, with particular focus on its potential regulation through inflammatory pathways and oxidative stress mechanisms.
Qiming Tan, Xiaoxuan Gong, Tian Wu, Chen Li, Kun Liu, Daorong Hou   +5 more
wiley   +1 more source

In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with in human fetal membranes-0

, 2011
Copyright information:Taken from "In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with in human fetal membranes"http://www.rbej.com/content/5/1/46Reproductive biology and endocrinology ...
Diana Soriano-Becerril (83604), Aurora Espejel-Nuñez (83602), Felipe Vadillo-Ortega (83607), Arturo Flores-Pliego (83603), Rolando Maida-Claros (83605), Veronica Zaga-Clavellina (83599), Hector Flores-Herrera (83601), Guadalupe Garcia-Lopez (83600), Horacio Merchant-Larios (83606)   +8 more
core   +1 more source

Ausência de associação entre polimorfismo do gene da interleucina-1 beta e o prognóstico de pacientes com traumatismo crânio-encefálico grave Lack of association between interleukin-1 gene polymorphism and prognosis in severe traumatic brain injury patients

Revista Brasileira de Terapia Intensiva, 2009
OBJETIVO: O traumatismo crânio-encefálico é a principal causa de óbito em indivíduos com idade entre 1 a 45 anos. O desfecho do traumatismo crânio-encefálico pode estar relacionado, além de fatores pré-morbidade e gravidade do dano, com fatores genéticos.
Taís Frederes Krämer Alcalde, Andrea Regner, Edison Moraes Rodrigues Filho, Patrícia Corso Silveira, Gabriela Gonçalves Grossi, Daniel Simon   +5 more
doaj   +1 more source

Cytokine patterns during dengue shock syndrome [PDF]

, 2003
Objective. To investigate the patterns of tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-6, interferon-c (IFN-c) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock syndrome. Design. Prospective clinical study.
Hack, C. Erik, van der Meer, Jos W. M., Dolmans, Wil M. V., Suharti, Catharina, van Gorp, Eric C. M., Setiati, Tatty E., Djokomoeljanto, Robert   +6 more
core   +1 more source

A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine and Immunologic Systems

Frontiers in Behavioral Neuroscience, 2016
The avoidance response is present in pathological anxiety and interferes with normal daily functions. The aim of this article is to shed light on performance markers of active avoidance (AA) using two different rat strains, Sprague-Dawley (SD) and Wistar.
Caroline Cruz Oliveira, Flavia Venetucci Gouveia, Marina Correia Castro, Mayra Akemi Kuroki, Lennon Cardoso Tosati Santos, Erich Talamoni Fonoff, Manoel Jacobsen Teixeira, Jose Pinhata Otoch, Raquel Chacon Ruiz Martinez   +8 more
doaj   +1 more source

Porphyromonas gingivalis culture supernatants differentially regulate interleukin-1beta and interleukin-18 in human monocytic cells [PDF]

, 2009
Porphyromonas gingivalis is a major bacterial species implicated in chornic periodontitis, a disease characterized by inflammatory destruction of the tooth supporting tissues.
Hamedi, M, Bostanci, N, Cruchley, A T, Curtis, M A, Belibasakis, G N, Rangarajan, M   +5 more
core   +1 more source

Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease

BMC Neuroscience, 2006
Background Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart
Qian Caiyun, Zhu Feiqi
doaj   +1 more source