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Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population

Neuroscience Letters, 2004
A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cytokine, interleukin-1beta (IL-1B ...
Esther Kahana   +2 more
exaly   +3 more sources

The Presence of Interleukin-1beta in the Bovine Reproductive Tract

Journal of Interferon & Cytokine Research, 1999
Interleukin-1 (IL-1) is a pleiotropic cytokine implicated in endometrial and embryonic physiology. Our objective was to determine the presence of IL-1 in the endometrium, oviduct, and uterine fluid of cows at days 0, 7, and 14 of the estrous cycle. Immunoreactive IL-1beta was identified in endometrial and oviductal tissues throughout the estrous cycle ...
F F, Paula-Lopes   +2 more
openaire   +2 more sources

A role for geranylgeranylation in interleukin‐1β secretion

Arthritis & Rheumatism, 2006
AbstractObjectiveMevalonate kinase deficiency (MKD) is an autosomal‐recessive disorder characterized by recurring episodes of inflammation. MK catalyzes the phosphorylation of mevalonic acid, which is an early step in isoprenoid biosynthesis. The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or ...
Mandey, Saskia H. L.   +3 more
openaire   +2 more sources

Evolution of interleukin-1β

Cytokine & Growth Factor Reviews, 2002
All jawed vertebrates possess a complex immune system, which is capable of anticipatory and innate immune responses. Jawless vertebrates possess an equally complex immune system but with no evidence of an anticipatory immune response. From these findings it has been speculated that the initiation and regulation of the immune system within vertebrates ...
Steve, Bird   +5 more
openaire   +2 more sources

Biological activity of human epidermal interleukin-1beta: comparison with recombinant human interleukin-1beta.

European cytokine network, 1998
We have recently presented evidence that human plantar stratum corneum and psoriatic scales contain biologically active interleukin-1beta (IL-1beta) which has been activated in a process not involving interleukin-1beta-converting-enzyme. The aim of the present study was to compare this form of native IL-1beta with recombinant mature human IL-1beta as ...
Nylander Lundqvist, E   +3 more
openaire   +2 more sources

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