Results 131 to 140 of about 23,893 (178)

[Interleukin-1beta and depressive states].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2002
Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite
O E, Zubareva, O M, Efremov, A S, Simbirtsev, V M, Klimenko   +3 more
openaire   +1 more source

Interleukin-1beta promotes repair of the CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001
Interleukin-1beta (IL-1beta) is a proinflammatory cytokine associated with the pathophysiology of demyelinating disorders such as multiple sclerosis and viral infections of the CNS. However, we demonstrate here that IL-1beta appears to promote remyelination in the adult CNS.
J L, Mason, K, Suzuki, D D, Chaplin, G K, Matsushima   +3 more
openaire   +1 more source

Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis

Clinical Oral Investigations
Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammatory cytokine interleukin-1beta (IL-1β) can increase Activin-A expression in various cell types. This study aims to evaluate gingival crevicular fluid (GCF)
Özden, Can, Afacan, Beral, İlhan, Harika Atmaca, Köse, Timur, Emingil, Gülnur   +4 more
openaire   +4 more sources

Interleukin-1beta gene in esophageal, gastric and colorectal carcinomas.

Oncology reports, 2007
Interleukin (IL)-1 gene polymorphisms are associated with development of gastric atrophy and with increased risk of gastric carcinoma. A -31C to T base transition in the promoter region of this gene is involved in carcinogenic changes within the stomach, especially in Helicobacter pylori infected individuals.
H, Ito, K, Kaneko, R, Makino, K, Konishi, T, Kurahashi, T, Yamamoto, A, Katagiri, Y, Kumekawa, Y, Kubota, T, Muramoto, K, Mitamura, M, Imawari   +11 more
openaire   +2 more sources

ICEBERG: a novel inhibitor of interleukin-1beta generation.

Cell, 2000
ProIL-1beta is a proinflammatory cytokine that is proteolytically processed to its active form by caspase-1. Upon receipt of a proinflammatory stimulus, an upstream adaptor, RIP2, binds and oligomerizes caspase-1 zymogen, promoting its autoactivation.
E W, Humke, S K, Shriver, M A, Starovasnik, W J, Fairbrother, V M, Dixit   +4 more
openaire   +1 more source

LL-Z1271alpha: an interleukin-1beta production inhibitor.

Biochemical and biophysical research communications, 2001
LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271alpha to LPS-challenged mice caused significant lowering in the IL-1beta levels in peritoneal cavity.
K, Ichikawa, T, Inagaki, H, Kachi-Tonai, Y, Kojima, T, Nakamura , H, Nishida, Y, Ueno, P, Binding, C A, Gabel, V, Lucas, P A, McNiff, N, Kojima   +11 more
openaire   +1 more source

Interleukin-1beta in the functional and structural luteolysis. Relationship with the nitric oxide system

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2002
The aim of the present report was to investigate the in vitro effect of interleukin-1beta(IL-1beta) on corpus luteum (CL) function and some aspects of this mechanism involved. Ovarian rat dispersates from mid-luteal phase were exposed to different doses of IL-1beta (1, 10, 20 ng/ml).
A, Estevez, T, Tognetti, B, Rearte, V, Sander, A B, Motta   +4 more
openaire   +2 more sources

Interleukin-1beta (IL-1beta) processing pathway.

Science signaling, 2010
The innate immune system senses molecular patterns from invading microorganisms. Once activated, it orchestrates the inflammatory response by secreting proinflammatory cytokines, such as interleukin-1 (IL-1)-type cytokines, in particular IL-1beta. IL-1 mediates the expression of a vast array of genes involved in secondary inflammation.
Axel, Weber, Peter, Wasiliew, Michael, Kracht   +2 more
openaire   +1 more source

Biological role of interleukin-1beta in defensive-aggressive behaviour.

Journal of biological regulators and homeostatic agents, 2011
During the past decade, a great deal of data has accumulated supporting the notion that cytokines interact to regulate several aspects of social and emotional behaviour. There are reports of a positive correlation between cytokine levels and aggressive behaviour in healthy populations, and clinical reports describe an increase of aggressive traits in ...
PESCE, MIRKO, SPERANZA, Lorenza, FRANCESCHELLI, SARA, Ialenti V, PATRUNO, ANTONIA, Febo MA, DE LUTIIS, Maria Anna, FELACO, Mario, GRILLI, Alfredo   +8 more
openaire   +2 more sources

Caspase‐1/interleukin‐1beta signaling in diabetic retinopathy

Acta Ophthalmologica, 2008
Abstract Purpose The pro‐inflammatory cytokine, interleukin‐1β (IL‐1β), is known to induce vascular dysfunction and cell death. Previously, we have shown that caspase‐1 activity is increased in retinas of diabetic and galactosemic mice, and diabetic patients.
openaire   +1 more source