Results 301 to 310 of about 517,111 (322)

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Analyse putativer Interleukin-23 Rezeptor interagierender Proteine

, 2022
openaire   +1 more source

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Artificial aptamer that inhibits interleukin-23/interleukin-23 receptor interaction discovered via SELEX

Biochemical and Biophysical Research Communications, 2022
Interaction between the pro-inflammatory cytokine interleukin-23 (IL-23) and IL-23 receptor (IL-23R) is related to the development of inflammatory autoimmune diseases such as psoriasis, inflammatory bowel disease, and Crohn's disease. In this study, we conducted systematic evolution of ligands by exponential enrichment (SELEX) for in vitro selection ...
Yukio Takamori, Takehiro Ando, Masashi Sato, Santhana Vedi, Daisuke Fuji, Takumi Yokoyama, Keita Tsukamoto, Mizuki Yamamoto, Takashi Kawakami   +8 more
openaire   +2 more sources

Interleukin-23: A New Atherosclerosis Target

Journal of Interferon & Cytokine Research, 2018
Accumulating evidence has shown that atherosclerosis is an inflammatory disease. The pathogenesis of atherosclerosis has been confirmed to involve an imbalance in anti-inflammatory/proinflammatory processes. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of the IL-23p19 and IL-12p40 subunits of the IL-12 family. Experiments show that IL-23
Wenjing, Liu, Chao, Chang, Haiying, Hu, Hua, Yang   +3 more
openaire   +2 more sources

Interleukin-23: Immunological roles and clinical implications

The International Journal of Biochemistry & Cell Biology, 2009
Increasing evidence has revealed the importance of IL-23, which closely resembles IL-12 both structurally and immunologically, in linking innate and adaptive immunity. IL-23, produced by activated type 1 macrophages and dendritic cells (DC), possesses unique roles in the differentiation and expansion of memory T cells.
Zi Yan, Tan, Kenneth W, Bealgey, Yong, Fang, Yang Ming, Gong, Shisan, Bao   +4 more
openaire   +3 more sources

Regulation of Memory T Cells by Interleukin-23

International Archives of Allergy and Immunology, 2016
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-
Yanchun, Li, Hongbo, Wang, Honghua, Lu, Shucheng, Hua   +3 more
openaire   +2 more sources

Reconciling id, ego, and superego within interleukin‐23

Immunological Reviews, 2008
Summary: The study of interleukin‐23 (IL‐23) over the past 8 years has led to the realization that cellular immunity is far more complex than previously appreciated, because it is controlled by additional newly identified players. From the analysis of seemingly straightforward cytokine regulation of autoimmune diseases, many limitations of the ...
Cristina M, Tato, Daniel J, Cua
openaire   +2 more sources

Microglia express a functional receptor for interleukin-23

Biochemical and Biophysical Research Communications, 2008
Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells.
Yoshifumi, Sonobe, Jiangfeng, Liang, Shijie, Jin, Guiqin, Zhang, Hideyuki, Takeuchi, Tetsuya, Mizuno, Akio, Suzumura   +6 more
openaire   +2 more sources

Interleukin-12, interleukin-23, and psoriasis: Current prospects

Journal of the American Academy of Dermatology, 2007
The clinical phenotype of psoriasis results from infiltration of T cells in the skin and elaboration of inflammatory cytokines. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to ...
Dorothea C, Torti, Steven R, Feldman
openaire   +2 more sources