Results 141 to 150 of about 62,501,450 (280)

Interleukin‐27: A master regulator in inflammation [PDF]

Arthritis & Rheumatism, 2011
openaire   +2 more sources

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

, 2010
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin ...
LA Zaffino (15871433), others (6644544), S Risis (13534441), TL Allen (15789329), MHS Chan (15871430), VB Matthews (15801491), DC Henstridge (14471430), JR Babb (15871358), PJ Meikle (9856718), James Boon (15871361), N Watson (8134650)   +10 more
core  

Systemic Reduction of Interleukin-4 or Interleukin-10 Fails to Reduce the Frequency or Severity of Experimental Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression

, 2012
Interleukin-4 (IL-4) and interleukin-10 (IL-10) are key cytokines whose increased production during systemic HIV infection has been associated with decreased cellular immunity during AIDS.
Hsin Chien, Richard D. Dix, Emily L. Blalock   +2 more
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Interleukin 27 Measurement [PDF]

, 2020
openaire   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Interleukin 27 in psoriasis: Friend or foe?

Indian Journal of Dermatology, Venereology and Leprology, 2022
Mohamed Hm, El-Komy, Heba, Ahmed, Ahmed, Mourad, Olfat Gamil, Shaker, Aya M, AlOrbani   +4 more
openaire   +2 more sources

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Peripheral Blood Levels of IL-27, IFABP, and DAO at Early Onset as Predictors of 28-Day Mortality in Enterogenic Sepsis Patients: A Single-Center, Prospective Pilot Study

Infection and Drug Resistance
Yin Ni,1,2 Renhua Sun,2 Bangchuan Hu,2 Jingquan Liu,2 Xiang-hong Yang,2 Jinzhu Wang2 1Hospital-Acquired Infection Control & Prevention and Health Care Department, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical ...
Ni Y, Sun R, Hu B, Liu J, Yang XH, Wang J   +5 more
doaj