Results 221 to 230 of about 139,988 (286)

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

<i>In ovo</i> carvacrol enriched inflammatory and T-cell transcriptional responses to <i>Escherichia coli</i> LPS in broiler chickens. [PDF]

Front Immunol
Meijer MMY, van den Brand H, Niknafs S, Roura E.   +3 more
europepmc   +1 more source

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Successful management of DPP-4 inhibitor-induced bullous pemphigoid with Stapokibart injection in an elderly diabetic patient: a case report. [PDF]

Front Med (Lausanne)
Yu M, Tian S, Meng F.
europepmc   +1 more source

Efficacy and Safety of Anti‐IL‐4Rα Stapokibart in Elderly Patients With Moderate‐To‐Severe Atopic Dermatitis

International Journal of Dermatology, EarlyView.
ABSTRACT Background Elderly patients with moderate‐to‐severe atopic dermatitis (AD) often exhibit more heterogeneous inflammatory profiles compared with younger adults. To evaluate the efficacy and safety of stapokibart, an anti‐interleukin‐4 receptor α subunit (IL‐4Rα) monoclonal antibody, in different age subgroups.
Yan Zhao, Litao Zhang, Liming Wu, Bin Yang, Jinyan Wang, Yumei Li, Qingchun Diao, Jingyi Li, Qing Sun, Xiaohong Zhu, Xiaoyong Man, Lihua Wang, Yanyan Feng, Tao Cai, Huiming Zeng, Linfeng Li, Jianyun Lu, Hong Ren, Fuqiu Li, Qianjin Lu, Xiaohua Tao, Rong Xiao, Chao Ji, Jing Sun, Yanping Qiu, Bo Chen, Jianzhong Zhang   +26 more
wiley   +1 more source

The Role of TNF-α in Ischemic Stroke. [PDF]

Int J Mol Sci
Kołodziejska R, Pawluk H, Tafelska-Kaczmarek A, Pawluk M, Koper K, Godlewski A, Kuk J, Sergot K, Kurhaluk N, Woźniak A.   +9 more
europepmc   +1 more source

Emerging mechanisms of ILC2‐neuronal crosstalk across the body

Immunology &Cell Biology, EarlyView.
Emerging roles of ILC2 in neuronal crosstalk across organs. In a series of studies published in 2025, ILC2 were shown to regulate nervous system function across a range of organs across the body. Within the intestinal tract, ILC2‐derived cytokines acted on enteric neurons to orchestrate immunity to helminths (Wang et al).
David A Posner, Matthew R Hepworth
wiley   +1 more source

Mechanisms of Gualou Beimu Yin in suppressing the development and metastasis of triple-negative breast cancer: an integrated study based on network pharmacology, transcriptomics, and metabolomics. [PDF]

J Tradit Chin Med
Ao J, Shuang L, Tingting G, Haoran Z, Wenyuan G, Xiongzhi WU.   +5 more
europepmc   +1 more source

Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy

Immunology &Cell Biology, EarlyView.
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong, Fernando Souza‐Fonseca‐Guimaraes   +1 more
wiley   +1 more source