Results 81 to 90 of about 139,988 (286)

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Catalytic receptors [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +5 more sources

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3

Cell Reports
Summary: Impaired β cell function is a hallmark of type 2 diabetes (T2D), but the underlying cellular signaling machineries that regulate β cell function remain unknown. Here, we identify that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known
Fan Yu, Shuting Xie, Tongyu Wang, Yeping Huang, Hong Zhang, Danfeng Peng, Yifan Feng, Yumei Yang, Zheyu Zhang, Yunxia Zhu, Zhuoxian Meng, Rong Zhang, Xiaomu Li, Hao Yin, Jie Xu, Cheng Hu   +15 more
doaj   +1 more source

Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies

Journal of Obesity, 2011
Interleukin-15 (IL-15) is a cytokine which inhibits lipid deposition in cultured adipocytes and decreases adipose tissue deposition in laboratory rodents.
LeBris S. Quinn, Barbara G. Anderson
doaj   +1 more source

Interleukin-6 and granulocyte colony-stimulating factor as predictors of the prognosis of influenza-associated pneumonia

BMC Infectious Diseases, 2022
Background Pneumonia is a common complication of influenza and closely related to mortality in influenza patients. The present study examines cytokines as predictors of the prognosis of influenza-associated pneumonia.
Jiaying Zhang, Jingxia Wang, Yiwen Gong, Yudan Gu, Qiangqiang Xiang, Ling-Ling Tang   +5 more
doaj   +1 more source

Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis. [PDF]

, 2017
Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin-17 (IL-17) is key in host defence in TB but its role in TB-driven tissue damage is unknown.
Aggarwal, Aguilo, Al Shammari, Aujla, Belton, Berg, Bermudez, Brinckerhoff, Chang, Cortez, Dheda, Dhiman, Domingo-Gonzalez, Elkington, Elkington, Elkington, Elkington, Elkington, Elkington, Fossiez, Freches, Fu, Gideon, Gopal, Hamburg, Hamburg, Happel, Hrabec, Huang, Jovanovic, Kubler, Leber, Matthews, Mayer-Barber, McAleer, McAllister, Miossec, Molet, Nuttall, O'Kane, O'Kane, Okamoto Yoshida, Ong, Oriss, Price, Qiao, Qiu, Rivas-Santiago, Ruddy, Sauty, Scriba, Singh, Singh, Sonnenberg, Torrado, Trajkovic, Treadwell, Volkman, Wang, Wickremasinghe, Wickremasinghe, Wong, Wozniak, Wu, Xu, Zijlstra   +65 more
core   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Agmatine Mitigates Acetaminophen-induced Acute Liver Injury in Mice: Involvement of HMGB1/RAGE/NFκB and Nrf2/HO-1 Signaling Pathways [PDF]

Journal of Applied Veterinary Sciences
An overdose of acetaminophen (APAP) is considered one of the primary sources of drug-induced liver injury. This study aimed to explore the mechanism of agmatine (Agma) against APAP-induced acute liver injury (ALI) in mice.
Ahmed Abdelhady, Mohammed Ayman, Marwa Abdelmageed   +2 more
doaj   +1 more source