Results 241 to 250 of about 1,897,702 (279)

Interleukin-38 Suppresses Cell Migration and Proliferation and Promotes Apoptosis of Colorectal Cancer Cell Through Negatively Regulating Extracellular Signal-Regulated Kinases Signaling

Journal of Interferon and Cytokine Research, 2021
Inflammatory cytokines has been of great interest in the field of colorectal cancer (CRC) tumor immunology in recent years. As an anti-inflammatory interleukin (IL), IL-38 may contribute to the early diagnosis of CRC and improve the prognosis of CRC ...
Lifeng Huang, Hongmei Zhang, Daniel Y Zhao, Hui Hu, Zhongxin Lu   +4 more
semanticscholar   +1 more source

Serum levels of novel anti-inflammatory cytokine Interleukin-38 in diabetes patients infected with latent tuberculosis (DM-LTB-3).

Journal of diabetes and its complications, 2022
IL-38 is a recently discovered, novel anti-inflammatory cytokine, which belongs to the IL-1β family. The role played by this cytokine in diabetes-tuberculosis nexus is not known.
V. Aravindhan, Anup Bobhate, Kuppan Sathishkumar, V. Viswanathan   +3 more
semanticscholar   +1 more source

Investigation of Interleukin-38 in patients with primary Sjögren’s Syndrome

Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, 2022
Aim: Interleukin-38 has been involved as an inflammatory mediator in rheumatic diseases. However, little is known about the role of IL-38 in the development of primary Sjögren’s syndrome. The present study aimed to evaluate the role of IL-38 in primary Sjögren’s syndrome and its clinical relevance.
Selcan GÜLTUNA, Sevinc CAN, Fevzi Nuri AYDİN   +2 more
openaire   +1 more source

Interleukin‐38 alleviates hepatic steatosis through AMPK/autophagy‐mediated suppression of endoplasmic reticulum stress in obesity models

Journal of Cellular Physiology
Interleukin‐38 (IL‐38), recently recognized as a cytokine with anti‐inflammatory properties that mitigate type 2 diabetes, has been associated with indicators of insulin resistance and nonalcoholic fatty liver disease (NAFLD). This study investigated the
Jaw Long Sun, W. Cho, Hee-Suk Oh, A. M. Abd El‐Aty, Soon Auck Hong, Ji Hoon Jeong, T. Jung   +6 more
semanticscholar   +1 more source

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Current Molecular Medicine, 2019
Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.
Jiangli, Zhu, Jing, Zhang, Yan, Wang, Jianping, Chen, Xiaopeng, Li, Xiangling, Liu, Eryan, Kong, Shao B, Su, Zhongjian, Zhang   +8 more
openaire   +2 more sources

Interleukin 38 improves insulin resistance in hyperlipidemic skeletal muscle cells via PPARδ/SIRT1-mediated suppression of STAT3 signaling and oxidative stress.

Biochemical and Biophysical Research Communications - BBRC
The cytokine interleukin-38 (IL-38), a recently discovered member of the IL-1 family, has been shown to regulate inflammation and improve hepatic endoplasmic reticulum stress and lipid metabolism in individuals with obesity.
Jaw Long Sun, Young Jin Kim, W. Cho, Do Su Lim, Hyeon Ji Gwon, A. M. Abd El‐Aty, Mehmet Akif Nas, Ji Hoon Jeong, T. Jung   +8 more
semanticscholar   +1 more source

Interleukin-38 ameliorates myocardial Ischemia-Reperfusion injury via inhibition of NLRP3 inflammasome activation in fibroblasts through the IL-1R8/SYK axis.

International Immunopharmacology
OBJECTIVE Although IL-38 is recognized for its regulatory role in a spectrum of chronic inflammatory diseases, investigations into its cardiac physiological and pathophysiological functions are nascent.
Chengliang Pan, Rui Shen, Yan Ding, Zhiyang Li, Chen Dong, Jiangmei Zhang, Ruirui Zhu, Kunwu Yu, Qiutang Zeng   +8 more
semanticscholar   +1 more source

Correlation of Rheumatoid Arthritis with Interleukin-38 and its Polymorphism (rs6743376)

Scandic Journal Of Advanced Research And Reviews, 2023
Among autoimmune disorders, rheumatoid arthritis is one of the most prevalent. The IL-1 family and the IL36 subfamily both include interleukin-38. IL-38 is anti-inflammatory cytokine. IL-38 is essential for inflammation control and host defense. In the Pakistani population, this research intends to evaluate the relationship flanked by IL-38 levels and ...
Mohammed Issa Ibrahim Islemeh, Bushra Mubarak, Amina Elahi   +2 more
openaire   +1 more source

Interleukin-38 Level and Polymorphism (Rs 6743376) Associated with Rheumatoid Arthritis

Scandic Journal Of Advanced Research And Reviews, 2023
Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder defined by persistent inflammation and joint damage. This study explores the intricate relationship between RA severity and interleukin-38 (IL-38), a cytokine having anti-inflammatory properties. Our research reveals a strong connection between elevated plasma IL-38 levels and the severity
Mohammed Issa Ibrahim Islemeh, Bushra Mubarak, Amina Elahi   +2 more
openaire   +1 more source

Serum levels of interleukin-38 in sufferers with atopic eczema

Egyptian Journal of Dermatology and Venerology, 2019
Background The relation between interleukin-38 (IL-38) and atopy is not precisely regarded yet. The current study has a look at set to assess the serum level of IL-38 in atopy patients and controls in order to illustrate the disease association and correlation with severity.
FathiaM Khattab, ElsayedM Khater, HodaA Ibraheem   +2 more
openaire   +1 more source