Results 91 to 100 of about 604,134 (278)

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

PERBANDINGAN KADAR SERUM HEAT SHOCK PROTEIN 90 (HSP90) DAN INTERLEUKIN-1β (IL-1β) PADA PREEKLAMSIA DAN KEHAMILAN NORMAL [PDF]

, 2017
ABSTRAK PERBANDINGAN KADAR SERUM HEAT SHOCK PROTEIN 90 (HSP90) DAN INTERLEUKIN-1β (IL-1β) PADA PREEKLAMSIA DAN KEHAMILAN NORMAL INGELIA Preeklamsia merupakan komplikasi kehamilan yang menyebabkan lebih dari 25% kematian ibu di Indonesia ...
Ingelia, Ingelia
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β.

PLoS Biology
Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β).
Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E Winter, Ron N Apte, Elena Voronov, Shai Bel   +21 more
doaj   +1 more source

Analysis of In Silico Interaction Campasterol of Alphitobius diaperinus with Interleukin 1β in Burn Conditions: Analisis Interaksi In silico Campasterol Kumbang Alphitobius diaperinus dengan Interleukin 1β pada Kondisi Luka Bakar

Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH)
Burns are a pathological condition that, if not managed properly, will cause wider damage. This study aims to analyze the potential of campasterol from the cage beetle Alphitobius diaperinus inhibitor IL-1β in burn conditions analyzed through in silico ...
Yossi Maryanti, Erfan Aritonang, Rahmawati Januar, Akbar Wicaksono, Yuli Susana, Detty Intan Sari, Irva Riandika, Putri Jelita Manulang, Fatmawati, Sri Wahyuni   +9 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

High-yield soluble expression of recombinant human interleukin-1β in Escherichia coli

, 2020
The pro-inflammatory cytokine interleukin-1β (IL-1β) is a key mediator of inflammation and is implicated in the ...
Kai Zhang, Xue Zhu, Ling Zhu, Yun Gao, K E Wang, Aiping Liu, Fanfan Zhou   +6 more
core  

Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes

, 2016
Interleukin-1β (IL-1β) is a key cytokine involved in inflammatory illnesses including rare hereditary diseases and common chronic inflammatory conditions as gout, rheumatoid arthritis, and type 2 diabetes mellitus, suggesting reduction of IL-1β activity ...
Maurer, Patrik, Saudan, P., Saudan, Philippe, Lässing, Ute, Seelig, E., Donath, M. Y., Bachmann, Martin, Spohn, Gunther, Donath, Marc Y, Osranek, Martin, Bachmann, M. F., Cavelti-Weder, Claudia, Müller, Philipp, Seelig, Eleonora, Jennings, Gary T, Timper, K., Keller, Cornelia, Timper, Katharina, Osranek, M., Willers, J., Spohn, G., Willers, Joerg, Muller, P., Jennings, G. T., Maurer, P., Lassing, U., Cavelti-Weder, C., Keller, C., Saudan P, Seelig E, Willers J, Lässing U, Jennings GT, Osranek M, Müller P, Bachmann MF, Spohn G, Cavelti-Weder C, Donath MY, Keller C, Maurer P, Timper K   +41 more
core   +1 more source

Inflammasome and IL-1β-Mediated Disorders [PDF]

, 2010
The NLRP3 inflammasome is an intracellular complex that regulates the release of proinflammatory cytokines such as interleukin-1β in response to exogenous pathogens and endogenous danger signals.
Alan A. Wanderer, Hoffman, Hal M., Hal M. Hoffman, Wanderer, Alan A.   +3 more
core   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High Body Mass Index

Arthritis Care &Research, EarlyView.
Objective High body mass index (BMI ≥ 27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source