Results 71 to 80 of about 604,134 (278)

Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)

Nutrition Journal, 2012
Background In vitro and animal studies have demonstrated that Chlorella is a potent biological response modifier on immunity. However, there were no direct evidences for the effect of Chlorella supplementation on immune/inflammation response in healthy ...
Kwak Jung, Baek Seung, Woo Yongje, Han Jae, Kim Byung Gon, Kim Oh, Lee Jong   +6 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Interleukin-1β gene is not associated with preeclampsia in Taiwanese

Taiwanese Journal of Obstetrics & Gynecology, 2012
Objective: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women. Methods and Materials: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β ...
Lin Kang, Chung-Hwan Chen, Chen-Hsiang Yu, Chiung-Hsin Chang, Fong-Ming Chang   +4 more
doaj   +1 more source

Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells [PDF]

, 2014
The rapid differentiation of monocytes into macrophages (MΦ) and dendritic cells is a pivotal aspect of the innate immune response. Differentiation is triggered following recognition of microbial ligands that activate pattern recognition receptors or ...
Philip T. Liu, Schenk, Mirjam, David M. Vu, Montoya, Dennis, Lee, Delphine J, Vu, David M, Delphine J. Lee, Krutzik, Stephan R, Mirjam Schenk, Mario Fabri, Liu, Philip T, Robert L. Modlin, Sieling, Peter A, Peter A. Sieling, Fabri, Mario, Stephan R. Krutzik, Dennis Montoya, Modlin, Robert L   +17 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Mechanisms of regulation for interleukin-1β in neurodegenerative disease

, 2007
The interleukin-1 family of cytokines are central to the pathology of acute and chronic diseases of the central nervous system. We describe current evidence on the transcriptional and post-transcriptional regulation of interleukin-1β production ...
Simi, Anastasia, Lerouet, Dominique, Anastasia Simi, David Brough, Emmanuel Pinteaux, Pinteaux, Emmanuel; id_orcid, Brough, David; id_orcid, Dominique Lerouet   +7 more
core   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Assoziationsstudie zu Interleukin-1β, Interleukin-6 und der Aktivität der lysosomalen sauren Sphingomyelinase in humanem Blut [PDF]

, 2012
1) Background and Aims There are studies showing a correlation between interleukin-1β (IL-1β), interleukin-6 (IL-6) and the activity of the acid sphingomyelinase (ASM).
Klüpfel, Thomas Alexander
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Therapy with canakinumab for gout

Научно-практическая ревматология, 2019
A significant part of patients with gout has contraindications to taking nonsteroidal anti-inflammatory drugs, colchicine and glucocorticoids. Such therapy is often ineffective, particularly in patients with the severe tophaceous gout what hampers ...
M. S. Eliseev, E. L. Nasonov
doaj   +1 more source