Results 51 to 60 of about 604,134 (278)

MOESM3 of Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

, 2019
Additional file 3. Flowchart of the extraction and isolation of oligostilbenes from Paeonia suffruticosa seed. 1 suffruticosol A, 2 suffruticosol B, 3 suffruticosol C, 4 trans-resveratrol, 5 cis-Îľ-viniferin, 6 trans-Îľ-viniferin, 7 cis-suffruticosol D, 8 cis-gnetin H, 9 trans-suffruticosol D, and 10 trans-gnetin H.
He, Yu-Kun, Cen, Xiao-tong, Liu, Shuang-shuang, Lu, Hua-ding, He, Chun-nian   +4 more
openaire   +1 more source

Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1β-Induced Stress And Apoptotic Death.

International journal of nanomedicine, 2019
Inflammatory stress caused by protein kinase D (PKD) plays a critical role in damaging chondrocytes and extracellular matrix (ECM) during osteoarthritis (OA). The PKD inhibitor (PKDi) (CRT0066101) has been used to overcome inflammation in different cell types.
Cho,Hongsik, Bhatti,Fazal-Ur-Rehman, Hasty,Karen A., Yi,Ae-Kyung   +3 more
openaire   +3 more sources

PENGARUH APLIKASI SUPLEMEN ZINC TERHADAP KADAR INTERLEUKIN-1β DALAM SALIVA TIKUS WISTAR JANTAN DENGAN PERIODONTITIS [PDF]

, 2018
Latar Belakang : Periodontitis adalah penyakit inflamasi pada jaringan periodontal yang memiliki prevalensi tertinggi di dunia. Biomarker seperti interleukin-1β dapat menjadi salah satu pertanda adanya penyakit periodontal.
Bintang, Wirya Putri
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

MOESM6 of Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

, 2019
Additional file 6. Immunofluorescence of Collagen II to identify primary chondrocytes. The Collagen Type II Antibody (Proteintech, USA) was used as the primary antibody. After the chondrocytes were incubated with goat anti-mouse immunoglobulin Alexa Fluor Plus 594 (1:200 dilution), they were stained red. The nuclei were stained with DAPI. After merging
He, Yu-Kun, Cen, Xiao-tong, Liu, Shuang-shuang, Lu, Hua-ding, He, Chun-nian   +4 more
openaire   +1 more source

Pattern of Interleukin-17A and Interleukin-1β in Migraine Patients [PDF]

Journal of Kerman University of Medical Sciences
Background: Migraine is a complex neurological disorder. The precise etiology of migraine is not clear. Many studies have been conducted on the association of the immune system with migraine pathophysiology.
Fardin Faraji, Ghasem Mosayebi, Afsoon Talaei, Hossein Ansari, Fatemeh Rafiei, Mobina Ravanbakhsh, Mana Shojapour   +6 more
doaj   +1 more source

Melatonergic signalling instructs transcriptional inhibition of IFNGR2 to lessen interleukin‐1β‐dependent inflammation

Clinical and Translational Medicine, 2022
Background Immunotransmitters (e.g., neurotransmitters and neuromodulators) could orchestrate diverse immune responses; however, the elaborated mechanism by which melatonergic activation governs inflammation remains less defined.
Yaoyao Xia, Qingzhuo Zhang, Yuyi Ye, Xiaoyan Wu, Fang He, Yuanyi Peng, Yulong Yin, Wenkai Ren   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source