Results 161 to 170 of about 63,552,420 (203)

Interleukin-18 and Crohn’s Disease

Digestion, 2001
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn’s disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological
T, Kanai, M, Watanabe, A, Okazawa, T, Sato, T, Hibi   +4 more
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Association of interleukin-18 and asthma

Inflammation, 2016
Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity.
Ming-Hui, Xu, Feng-Lai, Yuan, Shu-Jing, Wang, Hui-Ying, Xu, Cheng-Wan, Li, Xiao, Tong   +5 more
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Interleukin 18 and interleukin 18 binding protein in patients with idiopathic thrombocytopenic purpura

British Journal of Haematology, 2009
SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ning-Ning, Shan, Xiao-Juan, Zhu, Jun, Peng, Ping, Qin, Xue-Wei, Zhuang, Hong-Chun, Wang, Ming, Hou   +6 more
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Interleukin-12 but not interleukin-18 is associated with severe endometriosis

Fertility and Sterility, 2009
To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis.Cross-sectional survey.University hospital.Interleukin-12 and IL-18 levels were compared in 105 patients submitted to laparoscopy because of symptoms suggestive of endometriosis (pain and/or infertility).
Flávia, Fairbanks, Mauricio S, Abrão, Sergio, Podgaec, João Antonio, Dias, Ricardo M, de Oliveira, Luiz Vicente, Rizzo   +5 more
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Interleukin-18, interleukin-8, and CXCR2 and the risk of silicosis

Toxicology and Industrial Health, 2012
Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases.
Iraj, Mohebbi, Isa Abdi, Rad, Morteza, Bagheri   +2 more
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Interleukin 18: Friend or foe in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013
In the last few years, the field of tumor immunology has significantly expanded and its boundaries, never particularly clear, have become less distinct. Although the immune system plays an important role in controlling tumor growth, it has also become clear that tumor growth can be promoted by inflammatory immune responses.
Palma G, Barbieri A, Bimonte S, Palla M, Zappavigna S, CARAGLIA, Michele, Ascierto PA, Ciliberto G, Arra C.   +8 more
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Interleukin-18: recent advances

Current Opinion in Hematology, 2004
Interleukin-18 (IL-18) has potent immunomodulatory effects. It is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 polarization, depending on the immunologic context. Serum levels of IL-18 are increased in many human diseases and it has been implicated in the pathogenesis of several immune-mediated processes.
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Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage

Fertility and Sterility, 2011
To evaluate the association of interleukin-18 (IL-18) promoter single-nucleotide polymorphisms rs1946519 (-656C/A), rs187238 (-137G/C), rs360718 (-119A/C), and rs360717 (-105G/A) and changes in IL-18 serum levels with recurrent spontaneous miscarriage (RSM).Case-control study.Outpatient obstetrics and gynecology clinics.Women with confirmed RSM (n ...
Ghada M, Al-Khateeb, Mai S, Sater, Ramzi R, Finan, Fekria E, Mustafa, Amna S, Al-Busaidi, Manar A, Al-Sulaiti, Wassim Y, Almawi   +6 more
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Cloning of cDNA for Canine Interleukin-18 and Canine Interleukin-1beta Converting Enzyme and Expression of Canine Interleukin-18

Journal of Interferon & Cytokine Research, 1999
Cloning of canine interleukin-18 (IL-18) and canine interleukin-1beta converting enzyme (ICE) cDNA was carried out by using murine IL-18 cDNA and human ICE cDNA, respectively, as probes. Sequence homology to known sequences of human, mouse, or rat genes was noted at nucleotide and amino acid levels.
F, Okano, M, Satoh, T, Ido, K, Yamada
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Interleukins in cancer: from biology to therapy

Nature Reviews Cancer, 2021
Peter Libby, Daria Briukhovetska, Stefan Endres   +2 more
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