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Biological Agents Targeting Interleukin-18
Drug News & Perspectives, 2007Interleukin (IL)-18 is an important regulator of both innate and acquired immune responses. It is upregulated in several human autoimmune and inflammatory diseases, and, therefore, might represent a novel therapeutic target. This review highlights the biology of IL-18, its central role in inflammation and immune response, as well as provides evidence ...
Marija, Jelusic +2 more
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Shock, 2008
IL-18, originally termed as interferon gamma (IFN-gamma) inducing factor, is a proinflammatory cytokine that belongs to the IL-1 cytokine superfamily. IL-18 plays an important role in immune, infectious, and inflammatory diseases due to its induction of IFN-gamma.
Meijing, Wang +2 more
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IL-18, originally termed as interferon gamma (IFN-gamma) inducing factor, is a proinflammatory cytokine that belongs to the IL-1 cytokine superfamily. IL-18 plays an important role in immune, infectious, and inflammatory diseases due to its induction of IFN-gamma.
Meijing, Wang +2 more
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Interleukin-18: recent advances
Current Opinion in Hematology, 2004Interleukin-18 (IL-18) has potent immunomodulatory effects. It is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 polarization, depending on the immunologic context. Serum levels of IL-18 are increased in many human diseases and it has been implicated in the pathogenesis of several immune-mediated processes.
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Interleukin 18 and Periodontal Disease
Journal of Dental Research, 2007Cytokines are of major importance in periodontal disease progression. It is generally agreed that control of the Th1/Th2 balance is central to the immunoregulation of periodontal disease. There is increasing evidence in humans that the stable periodontal lesion is mediated by Th1 cells, while the progressive lesion sees a shift toward Th2 cells ...
Orozco, A. +3 more
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Interleukin-18 and Crohn’s Disease
Digestion, 2001The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn’s disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological
T, Kanai +4 more
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British Journal of Haematology, 2009
SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ning-Ning, Shan +6 more
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SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ning-Ning, Shan +6 more
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1985
Publisher Summary This chapter discusses the biochemical characterization and the physiological role of interleukin 1 (IL-1). IL-1 is a molecule that possesses a wide variety of biological activities. Biochemical studies reveal that IL-1 produced by stimulated murine macrophages and macrophage tumor cell lines is a single polypeptide chain.
William R. Benjamin +2 more
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Publisher Summary This chapter discusses the biochemical characterization and the physiological role of interleukin 1 (IL-1). IL-1 is a molecule that possesses a wide variety of biological activities. Biochemical studies reveal that IL-1 produced by stimulated murine macrophages and macrophage tumor cell lines is a single polypeptide chain.
William R. Benjamin +2 more
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Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD.
Hepato-gastroenterology, 2010The liver has been recognized as a major target of injury in patients with metabolic syndrome and non-alcoholic fatty liver disease has even been considered the hepatic manifestation of metabolic syndrome. Pathogenesis of non-alcoholic fatty liver disease remained unclear.
Yuan, Li +3 more
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