Results 51 to 60 of about 63,552,420 (203)

Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

Journal of Translational Medicine, 2018
Background The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on physiological functions.
Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga   +14 more
doaj   +1 more source

Human Keratinocytes Constitutively Express Interleukin-18 and Secrete Biologically Active Interleukin-18 After Treatment with Pro-Inflammatory Mediators and Dinitrochlorobenzene

, 1999
Interleukin-18 is a potent inducer of interferon-γ by activated T cells, macrophages, and monocytes and is synthesized as an inactive precursor. Pro-interleukin-18 must be cleaved by interleukin-1-β-converting enzyme for secretion of the biologically ...
Caughman, S. Wright, Ansel, John C., Naik, Shubhada M., Cannon, Georgetta, Wilcox, Josiah N., Burbach, Guido J., Singh, Sareeta R., Swerlick, Robert A.   +7 more
core   +1 more source

INTERLEUKIN-18 LEVELS IN SCHIZOPHRENIA PATIENTS RECEIVING ANTI-PSYCHOTIC THERAPY AT THE PSYCHIATRIC POLYCLINIC OF SITI RAHMAH ISLAMIC HOSPITAL

Jurnal Kedokteran dan Kesehatan
The use of antipsychotic therapy is effective in managing symptoms and has become a cornerstone in the treatment of patients with schizophrenia. However, antipsychotics have side effects on the immune system, particularly affecting Interleukin 18 (IL-18)
Dita Hasni, Debie Anggraini, Mutiara Anissa   +2 more
doaj   +1 more source

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation [PDF]

Nature Immunology, 2006
T helper type 1 (T$_{H}$1) lymphocytes are considered to be the main pathogenic cell type responsible for organ-specific autoimmune inflammation. As interleukin 18 (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous system inflammation.
Gutcher, Ilona, Urich, Eduard, Wolter, Karina, Prinz, Marco, Becher, Burkhard   +4 more
openaire   +5 more sources

Interleukin-6 levels in the control and AAA groups.

, 2023
There was no significant difference in plasma levels of IL-6 between groups (P = .17). AAA, abdominal aortic aneurysm; IL-6, interleukin-6.
Lenka Maliskova (8781746), Robert L. Raffai (12633072), Shant M. Vartanian (14614693), Adam Z. Oskowitz (14614696), Andrea J. Barczak (782932), Laura Bouchareychas (3493793), Michael S. Conte (12160976), Joshua D. Rudolph (14614690), Phat Duong (5718677), Jose L. Lopez (14614678), Tuan Anh Phu (14614684), Christina R. Kuhrau (14614687), Pei-Yu Lin (3370841), Walter L. Eckalbar (9243670), Joel L. Ramirez (14614681)   +14 more
core   +1 more source

Regulation of NK cell development and function by cytokines

Frontiers in Immunology, 2013
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines.
Antoine eMarçais, Sébastien eViel, Morgan eGrau, Thomas eHenry, Jacqueline eMarvel, Thierry eWalzer   +5 more
doaj   +1 more source

Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 in the Prediction of Acute Kidney Injury in Sepsis Patients. [PDF]

Int J Gen Med
Yajing Liu,1 Chunming Li,2 Xiaoya Yang,1 Shufen Guo,1 Zhaobo Cui,1 Hongshan Kang,1 Zhen Ma,1 Huiqing Wang1 1Intensive Care Unit, Hengshui People’s Hospital (Harrison International Peace Hospital), Hengshui, 053000, People’s Republic of China; 2Department
Liu Y, Li C, Yang X, Guo S, Cui Z, Kang H, Ma Z, Wang H.   +7 more
europepmc   +2 more sources

Interleukin-18 Stimulates a Positive Feedback Loop During Renal Obstruction via Interleukin-18 Receptor

, 2011
PURPOSE: Interleukin-18 is a proinflammatory cytokine that is an important mediator of obstruction induced renal tubulointerstitial fibrosis independent of tumor necrosis factor-α and β1 activity.
Karen Hile, Hiroshi Asanuma, Kirstan K. Meldrum, Hile, Karen, VanderBrink, Brian A., Rink, Richard C., Richard C. Rink, Asanuma, Hiroshi, Honji Zhang, Brian A. VanderBrink, Zhang, Honji, Meldrum, Kirstan K.   +11 more
core   +1 more source

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

Frontiers in Immunology, 2023
BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, it is
Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wróblewska, Marta Świtalska, Tomasz M. Goszczyński, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka   +8 more
doaj   +1 more source

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate [PDF]

, 2004
IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sj&
Blades, Mark C, I. B. Mcinnes, Conigliaro, Paola, Paola Conigliaro, Iain B McInnes, Priori, R, Barone, Francesca; id_orcid, Pittoni, Valerio, M. C. Blades, Pitzalis, C., Mark C Blades, Priori, R., M. Bombardieri, C. Pitzalis, ALESSANDRI, cristiano, Alessandri, C., Cristiano Alessandri, Bombardieri, M, Alessandri, C, VALESINI, Guido, McInnes, I B, Roberta Priori, Valesini, G., R. Priori, Conigliaro, P., Bombardieri, M., F. Barone, Valesini, G, Blades, M.C., P. Conigliaro, Pitzalis, C, V. Pittoni, Blades, M C, Pittoni, P., Pitzalis, Costantino, Michele Bombardieri, Conigliaro, P, Blades, MC, Pittoni, V, Bombardieri, Michele, Priori, Roberta, Barone, F., McInnes, I.B., Guido Valesini, Francesca Barone, McInnes, IB, McInnes, Iain B, Valerio Pittoni, Barone, F, Costantino Pitzalis   +49 more
core   +1 more source