Results 131 to 140 of about 32,812,329 (299)
The Journal of Pathology: Clinical ResearchIntraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh +7 more
doaj +1 more source
Structural and dynamic properties of IL1 receptors
Frontiers in ImmunologyThe study of the structural and dynamic properties of multidomain proteins is of great interest as they constitute one of the main regulatory mechanisms in the ligand–receptor system.
J. V. Zhukova +2 more
doaj +1 more source
Advanced Science, EarlyView.Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li +13 more
wiley +1 more source
Characterization of a gp130 Signaling Receptor Polymorphism [PDF]
, 2013 We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
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Interleukin-1[Alpha] production in periodontal disease: the interaction of bacteria and gene polymorphisms. [PDF]
, 2007 PhDThere is good evidence that interleukin-I alpha (IL-Ia) plays a key role in both the host response to bacteria and the tissue destruction associated with periodontal disease.
Bostanci, Nagihan
core +1 more source
Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low-resource settings [PDF]
Journal of Global Health, 2011 More than 500 000 children die each year in low resource settings due to serious neonatal infections. Better diagnostics that can be utilized in these settings to identify infected infants has the potential to significantly reduce neonatal deaths and ...
Thor A. Wagner +6 more
doaj
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
Caracterização do receptor e dos mecanismos relacionados a resposta inflamatoria induzida pela des-Arg9-bradicinina no modelo murino de pleurisia [PDF]
, 1998 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias BiologicasCaracterização do receptor B1, e dos mecanismos relacionados à resposta inflamatória induzida pela des-Arg9-bradicinina na cavidade pleural de camundongos.
Vianna, Rose Mari Jacobesen
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Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, EarlyView.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source
Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]
, 2011 We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane +10 more
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