Results 231 to 240 of about 23,313,489 (418)

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Targeting interleukin-2-inducible T cell kinase ameliorates immune-mediated aplastic anemia. [PDF]

Cancer Immunol Immunother
Li W, Lian Y, Zhang L, Li R, Liang Q, Mao J, Qiu C, Li H, Huang K, Li Q, Shen Y, Yang F, Tian L, Xiao T, Gu S, Pan H, Gao Z, Zhao J, Fang L, Ge M, Yuan W, Chu Y, Shi J.   +22 more
europepmc   +1 more source

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

, 1984
Shimon Efrat, Raymond Kaempfer
openalex   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source

Comparative real-world outcomes of stage III melanoma patients treated with talimogene laherparepvec or interleukin 2. [PDF]

Ther Adv Med Oncol
Reitmajer M, Nanz L, Müller N, Leiter U, Amaral T, Aebischer V, Flatz L, Forschner A.   +7 more
europepmc   +1 more source

Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. [PDF]

, 1988
J H Kehri, Mitchell Dukovich, Gail Whalen, Paul Katz, Anthony S. Fauci, Warner C. Greene   +5 more
openalex   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy. [PDF]

Sci Adv
Yang K, Bai B, Li X, Rou W, Huang C, Lu M, Zhang X, Dong C, Qi S, Liu Z, Yu G.   +10 more
europepmc   +1 more source

Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells

, 1984
Claudio Fiocchi, Mary Hilfiker, Kenneth R. Youngman, Nora C. Doerder, James H. Finke   +4 more
openalex   +1 more source

Interleukin 2 (IL 2) administered in vivo: influence of IL 2 route and timing on T cell growth. [PDF]

, 1985
Martin A. Cheever, John A. Thompson, D E Kern, Philip D. Greenberg   +3 more
openalex   +1 more source