Results 151 to 160 of about 1,035,200 (203)
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Science's STKE, 2005
Interleukin-4 (IL-4) is a cytokine produced by T H 2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between
Ann, Kelly-Welch +2 more
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Interleukin-4 (IL-4) is a cytokine produced by T H 2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between
Ann, Kelly-Welch +2 more
openaire +2 more sources
Journal of Immunological Methods, 1998
The present article describes procedures to measure rat IL-4 protein. The RT-PCR technique has been successfully and widely used to measure IL-4 mRNA, but it does not determine IL-4 protein synthesis. Assays to measure rat IL-4 protein based on its biological activity were developed using the mAb OX-81, which inhibits rat IL-4 activity.
Ramírez, F. +3 more
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The present article describes procedures to measure rat IL-4 protein. The RT-PCR technique has been successfully and widely used to measure IL-4 mRNA, but it does not determine IL-4 protein synthesis. Assays to measure rat IL-4 protein based on its biological activity were developed using the mAb OX-81, which inhibits rat IL-4 activity.
Ramírez, F. +3 more
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Interleukin 4, interleukin 4 receptor‐α and interleukin 10 gene polymorphisms in Chagas disease
Parasite Immunology, 2011SummaryIn this study, we investigated the association between single‐nucleotide polymorphisms (SNPs) of the interleukin‐4 (IL4), interleukin‐4 receptor‐α (IL4RA) and interleukin‐10 (IL10) genes with the development of chagasic heart disease. This study included 260 patients from Colombia who were serologically positive for Trypanosoma cruzi antigens ...
O, Flórez, J, Martín, C I, González
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Immunology and Allergy Clinics of North America, 2004
Interleukin 4 (IL-4) mediates important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus ...
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Interleukin 4 (IL-4) mediates important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus ...
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Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk
European Journal of Cancer, 2007Interleukin-4 (IL-4) and interleukin-4 receptor (IL-4R) modulate inflammation and are associated with the colorectal adenoma-carcinoma progression and the metastatic capacity. IL-4 also causes a dose-dependent reduction of proliferation in colorectal cancer cells.
LANDI, STEFANO +9 more
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Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy
Clinical Science, 1999Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy.
Gillespie, KM +4 more
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Interleukin‐4 and the interleukin‐4 receptor in allergic contact dermatitis
Contact Dermatitis, 1998Cutaneous immune responses involving T helper (TH) type 1 (TH1) and type 2 (TH2) T cells, characterised by secretion of interferon‐γ (Ifn‐γ) and interleukin‐4 (IL‐4), respectively, have both been reported in allergic contact dermatitis (ACD). We used immunohistochemistry to localize expression of IL‐4 in ACD lesions and unaffected skin.
A, Rowe, C B, Bunker
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Interleukin-4 and Interleukin-13 Signaling Connections Maps
Science, 2003Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy.
Ann E, Kelly-Welch +3 more
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1995
Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
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Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
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Differential bioassay of interleukin 2 and interleukin 4
Journal of Immunological Methods, 1987The T cell-derived lymphokines interleukin 2 (IL-2) and interleukin 4 (IL-4, originally BSF-1) both exhibit T cell growth-promoting activity. Recent observations that T cell lines commonly used as indicator cells in IL-2 bioassays also proliferate in response to IL-4 demonstrate the lack of specificity of these bioassays for IL-2.
S N, Ho +3 more
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