Results 191 to 200 of about 99,691,861 (294)

Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats. [PDF]

Theranostics
Alhalabi OT, Heene S, Zheng G, Heller R, Schubert T, Luzarowski M, Zha X, Walter J, Hansen-Palmus L, Biglari B, Wang XJ, Ruebenacker L, Skutella T, Kiening K, Schaaf CP, Krieg SM, Unterberg AW, Zweckberger K, Younsi A.   +18 more
europepmc   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Interleukin-4-mediated Pro-Regenerative Cellular Reprogramming in 3-dimensional Liver Culture. [PDF]

Cell Mol Gastroenterol Hepatol
Camat D, Nakib D, Chung SW, Sekhon M, Liu Y, Lumanto P, Hyduk SJ, Perciani CT, Bartczak AM, Cheng ML, Pezzutti OI, Kaltagian M, Altaf F, Jafari SM, Manuel J, Thoeni C, Ogawa S, Ma XZ, McGilvray ID, MacParland SA.   +19 more
europepmc   +1 more source

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Human interleukin-4-dependent facilitation of human IgG production in PBL-NOG-hIL-4-Tg mice. [PDF]

Front Immunol
Kametani Y, Ohshima S, Ito R, Ohno Y, Yamada S, Hoshino Y, Miyamoto A, Suzuki-Ohno M, Katano N, Tsuda B, Miyazawa M, Kashiwagi H, Kirigaya D, Shimizu T, Kojima M, Kikuchi Y, Nakada S, Ohki R, Yasuda A, Hirota A, Nakamura Y, Kulski JK, Mabuchi T, Ishimoto H, Shiina T.   +24 more
europepmc   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Interleukin-4 (IL-4) and Interleukin-4 Receptor Alpha Chain (IL-4Rα) Gene Polymorphisms in Egyptian Rheumatic Arthritis Patients [PDF]

Egyptian Journal of Pure and Applied Science, 2015
doaj   +1 more source

Quantitative analysis of interferon-γ and interleukin-4 levels in serum and saliva of oral lichen planus patients. [PDF]

Natl J Maxillofac Surg
Chaurasia A, Patil RK, Kaushik S, Ali W, Tiwari R, Heller D.   +5 more
europepmc   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source