Results 111 to 120 of about 81,908 (295)
Receptors for interleukin 4, interleukin 5 and interleukin 6.
Annali dell'Istituto superiore di sanita, 1991 cDNA encoding IL-4, IL-5 and IL-6 have been isolated and the availability of recombinant proteins allowed the demonstration of the pleiotropic effects of these cytokines. IL-4, IL-5 and IL-6 bind to high affinity receptors (Kd = 1-6 x 10(-10) M) expressed in low numbers on cells. The IL-4R is expressed on virtually every cell type whereas the IL-6R and
J, Banchereau, J P, Galizzi
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
Microarray results identifying specific interleukins modulated at days 3 and/or 7 post-injury.
, 2013 A total of 12 interleukins were significantly modulated (2 fold greater than normal and q-value
Stacey L. Brickson (440245) +6 more
core +1 more source
, 1995 Some interleukins, their receptors and alpha-1-acid glycoprotein as the indicators of immune activation in major ...
A Sluzewska (14575892) +4 more
core +1 more source
New Possibilities for the Treatment of Crohn’s Disease
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019 Aim. To review data on the efficiency and safety of using Ustekinumab in patients with Crohn’s disease.Key findings. Ustekinumab is a fully human monoclonal antibody of the IgG1k class to the p40 subunit of IL-12 and IL-23.
Z. A. Mamieva +2 more
doaj +1 more source
The International Journal of Biochemistry & Cell Biology, 1997 Interleukin-11 (IL-11) is an IL-6-type cytokine that is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. It binds to a multimeric receptor complex which contains an IL-11-specific alpha subunit and a promiscuous 130 kDa beta subunit (gp130). IL-11 stimulates multiple aspects of hematopoiesis and hepatocyte
S X, Leng, J A, Elias
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Endothelial Cell Proteins as Biomarkers in Susac Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin +11 more
wiley +1 more source
Balancing the Scales: The Dual Role of Interleukins in Bone Metastatic Microenvironments
Bone metastases, a common and debilitating consequence of advanced cancers, involve a complex interplay between malignant cells and the bone microenvironment. Central to this interaction are interleukins (ILs), a group of cytokines with critical roles in
Khalid S. Mohammad +2 more
core +1 more source
Association of Interleukins Genes Polymorphic Markers with Speed of CGN’s Advance
, 2020 The authors investigated associations of polymorphism of interleukins genes with nephritic survivance of the ill with chronic glomerulonephritis among 238 patients with CGN and 241 control group ...
Churnosov, M. I. +4 more
core
Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang +7 more
wiley +1 more source