Results 121 to 130 of about 46,488 (301)

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

ApoVLDL of the Watanabe Heritable Hyperlipidemic rabbit and the cholesterol-fed rabbit.

Journal of Lipid Research, 1984
The Watanabe Heritable Hyperlipidemic rabbit (WHHL rabbit) and the cholesterol-fed rabbit have been reported to show elevations of very low density (VLDL), intermediate density (IDL), and low density lipoproteins (LDL), and a broad-beta band on agarose ...
T Wakasugi, H Mabuchi, Y Sakai, T Sakai, A Yoshimura, A Watanabe, J Koizumi, S Miyamoto, R Takeda, Y Watanabe   +9 more
doaj  

Studies on abnormalities in serum intermediate density lipoproteins during maintenance hemodialysis

, 1987
園部 美弥彦, 湯川 進, 西川 治, 日比野 彰, 宮井 利彦, 前田 孝夫, 野本 拓, 西川 紀子, 西出 巌   +8 more
openalex   +2 more sources

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Selective accumulation of low density lipoproteins in damaged arterial wall.

Journal of Lipid Research, 1983
To determine whether damaged arterial wall selectively accumulates lipoproteins, normocholesterolemic rabbits were injected with human radiolabeled low density lipoproteins, high density lipoproteins, and/or albumin 24 hr to 12 weeks after balloon ...
A B Roberts, A M Lees, R S Lees, H W Strauss, J T Fallon, J Taveras, S Kopiwoda   +6 more
doaj  

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

Cosegregation of Aortic Root Atherosclerosis and Intermediate Lipid Phenotypes on Chromosomes 2 and 8 in an Intercross of C57BL/6 and BALBc/ByJ Low-Density Lipoprotein Receptor ^−/− Mice [PDF]

, 2011
Ralph Burkhardt, Simon Sündermann, Doris Ludwig, Uta Ceglarek, Lesca M. Holdt, Joachim Thiery, Daniel Teupser   +6 more
openalex   +1 more source

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

Advanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang, Wen‐Chi Xue, Chao Liang, Pan Liu, Yao Lei, Jiaqi He, Ran Cheng, Weidong Nie, Jianxiong Wang, Jie Tang, Hai‐Yan Xie   +10 more
wiley   +1 more source

Intermediate-density lipoprotein as an indipendent risk factor for coronary artery disease

, 1999
Takeshi Kurata, Hiroshi Mokuno, Hiroyuki Daida, Tatsuji Kanoh, Hiroshi Yamaguchi   +4 more
openalex   +2 more sources

Low‐density lipoprotein‐cholesterol lowering in individuals at intermediate cardiovascular risk: Percent reduction or target level? [PDF]

, 2018
Fernando Yue Cesena, Antônio Gabriele Laurinavicius, Viviane A. Valente, Raquel Conceição, Raúl D. Santos, Márcio Sommer Bittencourt   +5 more
openalex   +1 more source