Results 131 to 140 of about 303,727 (299)

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Increased de novo Lipogenesis and Delayed Conversion of Large VLDL into Intermediate Density Lipoprotein Particles Contribute to Hyperlipidemia in Glycogen Storage Disease Type 1a

Pediatric Research, 2008
R. Bandsma, B. Prinsen, M. G. M. de Sain-van der Velden, J. Rake, T. Boer, G. Smit, D. Reijngoud, F. Kuipers   +7 more
semanticscholar   +1 more source

Secondary structure in very low density and intermediate density lipoproteins of human serum.

, 1979
G C Chen, John P. Kane
openalex   +1 more source

SP308ASSOCIATION OF HIGH DENSITY LIPOPROTEINS WITH ESTIMATED GLOMERULAR FILTRATION RATE IN PARTICIPANTS WITH INTERMEDIATE AND HIGH RISK OF CARDIOVASCULAR DISEASE [PDF]

, 2015
Domagoj Marković, Branimir Marković, Damir Fabijanić, Vedran Kovačić   +3 more
openalex   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Antiretroviral treatment reduces very-low-density lipoprotein and intermediate-density lipoprotein apolipoprotein B fractional catabolic rate in human immunodeficiency virus-infected patients with mild dyslipidemia.

Journal of Clinical Endocrinology and Metabolism, 2005
M. Shahmanesh, Satyajit Das, M. Stolinski, F. Shojaee-Moradie, Nicola C. Jackson, W. Jefferson, R. Cramb, P. Nightingale, A. Umpleby   +8 more
semanticscholar   +1 more source

Effects of Olive Oil Administration on Apoprotein B-48 Distribution in Very Low Density Lipoproteins, Intermediate Density Lipoproteins and Low Density Lipoproteins in Patients on Maintenance Hemodialysis

, 1984
Toshihiko MIYAI, Susumu Yukawa, Takao MAEDA, Masahiro Kinoshita, Keiji MIMURA, Kazuo Mori, Hiroshi Nomoto   +6 more
openalex   +2 more sources

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Increased small dense LDL and intermediate-density lipoprotein with albuminuria in type 1 diabetes.

Diabetes Care, 1999
S. Sibley, J. Hokanson, M. Steffes, J. Purnell, S. Marcovina, P. Cleary, J. Brunzell   +6 more
semanticscholar   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source