Results 201 to 210 of about 46,488 (301)

Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities

Arthritis &Rheumatology, EarlyView.
Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley   +1 more source

Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction. [PDF]

Stroke Vasc Neurol
Wang J, Liu Z, Hu C, Zhao R, Zhu D, Xie Y, Zhang P, Cui M, Xu K, Zhao G, Jin L, Chen X, Suo C, Jiang Y.   +13 more
europepmc   +1 more source

Monocyte‐derived macrophages‐synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Energy landscape analysis of health checkup data clarified multiple pathways to diabetes development in obese and non-obese subjects. [PDF]

Front Endocrinol (Lausanne)
Ito R, Oku M, Kimura I, Haruki T, Shikata M, Teramoto T, Chujo D, Iwata M, Fujisaka S, Nagata Y, Yamagami T, Kadowaki M, Tobe K, Saito S, Ueda K.   +14 more
europepmc   +1 more source

Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram‐Negative Bacteria

Chemistry – An Asian Journal, EarlyView.
The lipoprotein transport system (Lol) is a crucial target for combating multidrug‐resistant gram‐negative bacteria. This review discusses the structural and functional aspects of the LolABCDE complex, recent advances in small‐molecule inhibitors, and challenges, such as permeability and resistance.
Saemee Song, Su Yong Shim
wiley   +1 more source

Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with cardiovascular disease risk in patients with metabolic dysfunction-associated fatty liver disease: a cross-sectional NHANES analysis. [PDF]

Front Nutr
Wang X, Shi Y, Zi Y, Long J, Shi R.
europepmc   +1 more source

Fabrication of Polypyrrole–Polystyrene Sulfonate by Amperometric Biosensor‐Based Electropolymerization for Cholesterol Determination in Serum

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Since cholesterol triggers many diseases, many methods have been developed for its determination. In this study, an alternative system for cholesterol determination was developed by preparing amperometric biosensors. In the development of the biosensor, Pt/polypyrrole–polystyrene sulfonate film was prepared by electropolymerization of ...
Alaa Anwer Ali Dada, Ertan Yildirim, Sinan Mithat Muhammed, Servet Çete   +3 more
wiley   +1 more source

Lipid Dysregulation in Tangier Disease: A Case Series and Metabolic Characterization.

J Clin Endocrinol Metab
Semmler G, Baumgartner C, Metz M, Gensluckner S, Habisch H, Hofer H, März W, Offner F, Völkerer A, Petrenko O, Wernly B, Draxler-Dworzak S, Neyer M, Nigmann C, Greber-Platzer S, Esterbauer H, Madl T, Aigner E, Scherer T, Datz C.   +19 more
europepmc   +1 more source

Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study. [PDF]

J Ovarian Res
Zhang Y, Zhang M, Cai M, Shao X, Dilimulati D, Lu J, Zhu C, Chen H, Li C, Qu S, Zhang M.   +10 more
europepmc   +1 more source

How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration

BioEssays, EarlyView.
Migrating neurons and growing axons utilize structurally and functionally similar growth cones to detect guidance cues. Shared receptors and signaling pathways mediate cytoskeletal reorganization to direct movement. This conserved mechanism underlies both neuronal migration and axon extension, providing insights into neuronal development and potential ...
Takahiro Kanzawa, Chikako Nakajima, Masato Sawada, Kazunobu Sawamoto   +3 more
wiley   +1 more source