Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes
ChemElectroChem, EarlyView.This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský +5 more
wiley +1 more source
Alpha-lipoic acid on intermediate disease markers in overweight or obese adults: a systematic review and meta-analysis. [PDF]
BMJ OpenLuo Y, Zhang J, Guo H.
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A class of directed acyclic graphs with mixed data types in mediation analysis
Canadian Journal of Statistics, EarlyView.Abstract We propose a unified class of generalized structural equation models (GSEMs) with data of mixed types in mediation analysis, including continuous, categorical, and count variables. Such models extend substantially the classical linear structural equation model to accommodate many data types arising from the application of mediation analysis ...
Wei Hao, Canyi Chen, Peter X.‐K. Song
wiley +1 more source
Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses. [PDF]
Br J CancerYuan F +9 more
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ChemMedChem, EarlyView.Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore +5 more
wiley +1 more source
Elevated plasma concentrations of lipoprotein (a) are associated with cardiovascular diseases in patients with early-onset type 2 diabetes mellitus. [PDF]
Front Endocrinol (Lausanne)Zhang J +11 more
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Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Performance evaluation of the Cobas c 703 analytical unit as part of Cobas Pro integrated solutions using LED as the sole photometric light source. [PDF]
Pract Lab MedFindeisen P +4 more
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Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
Association between serum homocysteine levels and advanced hepatic fibrosis in alcohol-related liver disease: A cross-sectional study of NHANES. [PDF]
Medicine (Baltimore)Ma C, Zhang X, Zhang W, Duan J, Yang H.
europepmc +1 more source