Results 41 to 50 of about 303,727 (299)

Effects of bezafibrate on apolipoprotein B metabolism in type III hyperlipoproteinemic subjects.

Journal of Lipid Research, 1990
This study was designed to investigate the response of Type III hyperlipoproteinemic subjects to bezafibrate therapy. The metabolism of apolipoprotein B was examined in four lipoprotein subclasses of Sf 60-400 (large very low density lipoprotein (VLDL)),
C J Packard, R J Clegg, M H Dominiczak, A R Lorimer, J Shepherd   +4 more
doaj   +1 more source

Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

Frontiers in Molecular Biosciences, 2021
Coronavirus disease 2019 (COVID-19) is a viral infection affecting multiple organ systems of great significance for metabolic processes. Thus, there is increasing interest in metabolic and lipoprotein signatures of the disease, and early analyses have ...
Franziska Schmelter, Franziska Schmelter, Bandik Föh, Bandik Föh, Alvaro Mallagaray, Johann Rahmöller, Johann Rahmöller, Marc Ehlers, Selina Lehrian, Vera von Kopylow, Inga Künsting, Anne Sophie Lixenfeld, Emily Martin, Mohab Ragab, Roza Meyer-Saraei, Roza Meyer-Saraei, Fabian Kreutzmann, Fabian Kreutzmann, Ingo Eitel, Ingo Eitel, Stefan Taube, Nadja Käding, Eckard Jantzen, Tobias Graf, Tobias Graf, Christian Sina, Christian Sina, Ulrich L. Günther   +27 more
doaj   +1 more source

A Woman With Hypertriglyceridemia Who Acquired Antibody Against GPIHBP1

JACC: Case Reports, 2020
We report a case of a woman with primary hypertriglyceridemia caused by acquired glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) autoantibody. This case highlights the necessity of detecting GPIHBP1 autoantibody
Yuka Hirano, MD, Yasunori Suematsu, MD, PhD, Yuiko Yano, MD, PhD, Shuichi Sato, MD, PhD, Shin-Ichiro Miura, MD, PhD   +4 more
doaj   +1 more source

Quantification of cholesterol in all lipoprotein classes by the VAP-II method.

Journal of Lipid Research, 1994
We have developed a high resolution microvolume Vertical Auto Profile (VAP) method for the simultaneous measurement of cholesterol in all lipoprotein classes, including lipoprotein[a] (Lp[a]) and intermediate density lipoprotein (IDL).
K R Kulkarni, D W Garber, S M Marcovina, J P Segrest   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A comprehensive metabolic profiling of the metabolically healthy obesity phenotype

Lipids in Health and Disease, 2020
Background The ever-increasing prevalence of obesity constitutes a major health problem worldwide. A subgroup of obese individuals has been described as “metabolically healthy obese” (MHO).
Vibeke H. Telle-Hansen, Jacob J. Christensen, Gulla Aase Formo, Kirsten B. Holven, Stine M. Ulven   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity

Journal of Lipid Research, 2000
Hepatic lipase (HL) is a key player in lipoprotein metabolism by modulating, through its lipolytic activity, the triglyceride (TG) and phospholipid content of apolipoprotein B (apoB)-containing lipoproteins and of high density lipoproteins (HDL), thereby
Alberto Zambon, Samir S. Deeb, Andre Bensadoun, Karen E. Foster, John D. Brunzell   +4 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source