Results 71 to 80 of about 2,434,460 (293)

Identification of pancreatic cancer invasion-related proteins by proteomic analysis [PDF]

, 2009
Background – Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model of pancreatic cancer ...
Naomi Walsh, Walsh Naomi, Martin Clynes, Meleady Paula, Henry Michael, Clynes, Martin, Kennedy Susan, Susan Kennedy, O'Donovan, Norma, Clynes Martin, Michael Henry, Walsh, Naomi, Dowling, Paul, Paula Meleady, O'Donovan Norma, Meleady, Paula, Norma O'Donovan, Kennedy, Susan, O\u27Donovan, Norma, Henry, Michael, Dowling Paul, Paul Dowling   +21 more
core   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

MCLIP Detection of Novel Protein–Protein Interactions at the Nuclear Envelope

, 2016
The organization and function of the nuclear envelope (NE) involves hundreds of nuclear membrane proteins and myriad protein-protein interactions, most of which are still uncharacterized.
Einar Hallberg, Hallberg, Einar,, Ricardo A. Figueroa, Mohammed Hakim Jafferali, Jafferali, Mohammed Hakim,, Figueroa, Ricardo A.,   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The N-terminal domain of Escherichia coli RecA have multiple functions in promoting homologous recombination

Journal of Biomedical Science, 2009
Escherichia coli RecA mediates homologous recombination, a process essential to maintaining genome integrity. In the presence of ATP, RecA proteins bind a single-stranded DNA (ssDNA) to form a RecA-ssDNA presynaptic nucleoprotein filament that captures ...
Wang Ting-Fang, Lee Chien-Der
doaj   +1 more source

GFAP at 50

ASN Neuro, 2020
Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse as ...
Albee Messing, Michael Brenner
doaj   +1 more source

Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni [PDF]

, 2008
© 2008 Lockyer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Rollinson, D, Spinks, Jenny, Jennifer M Fitzpatrick, Hoffmann, Karl F, David Rollinson, Rollinson, David, Leslie R Noble, Lockyer, AE, Fitzpatrick, JM, Lockyer Anne E, Hoffmann, KF, Jenny Spinks, Hoffmann Karl F, Noble, Leslie R, Jones, Catherine S, Karl F Hoffmann, Noble, LR, Kane, RA, Catherine S Jones, Rollinson David, Anne E Lockyer, Jones, CS, Spinks, J, Fitzpatrick Jennifer M, Richard A Kane, Noble Leslie R, Lockyer, Anne E, Kane Richard A, Fitzpatrick, Jennifer M., Kane, Richard A., Spinks Jenny, Jones Catherine S   +31 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Rapid transport of neural intermediate filament protein [PDF]

Journal of Cell Science, 2003
Peripherin is a neural intermediate filament protein that is expressed in peripheral and enteric neurons, as well as in PC12 cells. A determination of the motile properties of peripherin has been undertaken in PC12 cells during different stages of neurite outgrowth.
Brian T, Helfand, Patty, Loomis, Miri, Yoon, Robert D, Goldman   +3 more
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source