Results 111 to 120 of about 948,768 (269)

Dysregulated monocyte compartment in PACS patients

Frontiers in Immunology
Introduction1-5% of all patients with COVID-19, a disease caused by infection with Severe Acute Respiratory Syndrome Virus 2 (SARS-Cov-2), even those with mild COVID-19 symptoms, continue to have symptoms after initial recovery.
Romy Kronstein-Wiedemann, Romy Kronstein-Wiedemann, Madeleine Teichert, Elisa Michel, Janina Berg, George Robinson, Kristin Tausche, Kristin Tausche, Martin Kolditz, Martin Kolditz, Johannes Bergleiter, Jessica Thiel, Jessica Thiel, Dirk Koschel, Dirk Koschel, Dirk Koschel, Stephan R. Künzel, Stephan R. Künzel, Kristina Hölig, Kristina Hölig, Kristina Hölig, Torsten Tonn, Torsten Tonn, Torsten Tonn, Manuela Rossol, Manuela Rossol   +25 more
doaj   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Inflammatory dysregulation of monocytes in pediatric patients with obsessive-compulsive disorder

Journal of Neuroinflammation, 2017
Background Although the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there is growing evidence of a role for immune dysregulation in the pathophysiology of the disease, especially in the innate immune system including the microglia ...
Natalia Rodríguez, Astrid Morer, E. Azucena González-Navarro, Carles Serra-Pages, Daniel Boloc, Teresa Torres, Susana García-Cerro, Sergi Mas, Patricia Gassó, Luisa Lázaro   +9 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16-Monocytes

, 2019
Monocytes in humans consist of 3 subsets; CD14+CD16−(classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation.
Bertuzzo Veiga, C (15701750), Shihata, WA (15701747), Palmer, CS (15694022), Cooney, OD (15701753), Claeson, E (15701762), Fleetwood, AJ (15701756), Murphy, AJ (15559433), Lee, MKS (15701741), Flynn, MC (15701759), Henstridge, DC (15701765), Hamilton, JA (15701768), Al-sharea, A (15701744)   +11 more
core  

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Establishment of THP-1 Monocytes with Compromised Mitochondrial Functions [PDF]

, 2009
The process of inflammation is important for both normal health and in a number of diseases, such as metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Mitochondria are vital for the functioning of all cells. It had been implicated
Chou, Tzu-wen Joy
core  

Levels of Circulating Intermediate Monocytes Decrease after Aortic Valve Replacement in Patients with Severe Aortic Stenosis

, 2017
Aortic valve stenosis (AS) is a chronic inflammatory disease. We have previously shown that severe AS is associated with increased levels of circulating intermediate monocytes.
Herko Grubitzsch, Rena Ellerbroek, Verena Stangl, Antje Ludwig, Karl Stangl, Fabian Knebel, Bernd Hewing, Michael Laule, Gert Baumann, Henryk Dreger, Sebastian Au   +10 more
core   +1 more source

Design of a Robust Flow Cytometric Approach for Phenotypical and Functional Analysis of Human Monocyte Subsets in Health and Disease

Biomolecules
Human monocytes can be subdivided into phenotypically and functionally different classical, intermediate and non-classical monocytes according to the cell surface expression of CD14 and CD16.
Talia Ahrazoglu, Jennifer Isabel Kluczny, Patricia Kleimann, Lisa-Marie Irschfeld, Fabian Theodor Nienhaus, Florian Bönner, Norbert Gerdes, Sebastian Temme   +7 more
doaj   +1 more source