Results 61 to 70 of about 38,089 (218)

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Effect of intermittent normobaric hypoxia on the morphological changes in the respiratory part of lungs in different seasons of the year

Journal of Education, Health and Sport, 2018
The purpose of this work was to study and compare the effect of intermittent normobaric hypoxia on the morphological and biochemical indices of the functional state and structure of the respiratory part of the lungs in the spring and autumn.
Roman Yanko, Michail Levashov, Elena Chaka, Irina Litovka   +3 more
doaj   +3 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Melatonin alleviates chronic intermittent hypoxia-induced gastric mucosal injury via attenuation of oxidative stress and JNK-mediated apoptotic signaling in rats.

PLoS ONE
BackgroundTo investigate the mechanism of chronic intermittent hypoxia on gastric injury in rats and the intervening effect and possible mechanism of melatonin.MethodsForty-eight male Wistar rats were randomly divided into normal control, intermittent ...
Hong L Ji, Hua L Yu, Jia F Luo, Xin R Li, Cheng X Nie, Tie J Liu, Huan H Jiang, Cong H Liu, Jia B Zhang, Xin H Yuan, Xiao F Song, Yue D Li, Yanlei Ge, Ai S Fu   +13 more
doaj   +1 more source

Fetal autonomic responses inferred from heart rate variability during recurrent decelerations without acidosis—An observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Recurrent fetal heart rate (FHR) decelerations without acidosis are frequently observed during labor; however, the underlying autonomic mechanisms remain incompletely understood. This study explored fetal autonomic responses to recurrent decelerations using FHR and FHR variability (FHRV) parameters.
Shoichi Magawa, Masafumi Nii, Yuya Tamaishi, Asumi Okumura, Sho Takakura, Shintaro Maki, Kuniaki Toriyabe, Erina Takayama, Eiji Kondo, Tomoaki Ikeda   +9 more
wiley   +1 more source

Hypoxia Suppresses TGF-B1-Induced Cardiac Myocyte Myofibroblast Transformation by Inhibiting Smad2/3 and Rhoa Signaling Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hypoxia modulation of transforming growth factor (TGF)- β-induced signaling during myofibroblast transformation is dependent on the specific cell type.
Zhankui Yan, Daifei Shen, Jilin Liao, Yanmei Zhang, Yicun Chen, Ganggang Shi, Fenfei Gao   +6 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Intermittent hypoxic perconditioning improves cognitive function in a mouse model of vascular cognitive impairment and dementia with comorbidities by recovering cerebral blood flow

Neural Regeneration Research
Vascular cognitive impairment and dementia is a debilitating neurological disorder caused by chronic cerebral hypoperfusion, for which no effective causative treatments are currently available.
Feiyang Jin, Zhengming Tian, Yuying Guan, Yuning Li, Yakun Gu, Mengyuan Guo, Qianqian Shao, Yingxia Liu, Xiuhai Guo, Zhenzhen Quan, Jia Liu, Xunming Ji   +11 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source