Results 71 to 80 of about 12,238,800 (263)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Aneurisma da artéria carótida interna Aneurysm of the internal carotid artery
Jornal Vascular Brasileiro, 2013 Os aneurismas de artéria carótida interna (ACI) extracraniana são raros. Há poucos relatos na literatura médica quanto à sua etiologia, relacionando-os à doença aterosclerótica, às arterites e alterações decorrentes do trauma ou após procedimento ...
Ludvig Hafner +7 more
doaj
Frontiers in SurgeryBackgroundThe use of traditional sacroiliac screws in the treatment of Day type II crescent fracture-dislocation of the pelvis (CFDP) is often associated with insufficient screw anchorage and compression due to the short iliac segment of the screw and ...
Renjie Li +6 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Sublogarithmic fluctuations for internal DLA
, 2013 We consider internal diffusion limited aggregation in dimension larger than or equal to two. This is a random cluster growth model, where random walks start at the origin of the d-dimensional lattice, one at a time, and stop moving when reaching a site ...
Asselah, Amine, Gaudillière, Alexandre
core +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Treatment of medial epicondyle fractures accompanying elbow dislocations in children
Acta Orthopaedica et Traumatologica Turcica, 2020 Objectives: We evaluated the clinical and radiographic results of treatment for medial epicondyle fractures accompanying elbow dislocations in children.\nMethods: The study included 10 children (9 boys, 1 girl; mean age 12 years; range 1.5 to 15 years ...
Guven Bulut +4 more
doaj
Sosial Budaya, 2013 Evaluation of the implementation of the Internal Quality Assurance System (SPMI) in college has been implemented by a working group within the Directorate of Academic. State Islamic University implementation of internal audit college.
Novi Yanti
doaj +1 more source