Results 51 to 60 of about 2,362,923 (282)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Internal or External Grounds for the Nontransitivity of “Better/Worse than”

Law, Ethics and Philosophy, 2015
In his book Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning Larry Temkin contrasts two views of ideals for evaluating outcomes: the Internal Aspects View and the Essentially Comparative View.
Ingmar Persson
doaj  

The Role of Interactive Technologies, Virtual Reality and Artificial Intelligence in Teaching Propaedeutics of Internal Diseases: Perspectives from Teachers and Students

Juvenis Scientia
The present review is a critical view of the teachers of the Department of Propaedeutics of Internal Diseases and students on the current problems of teaching clinical disciplines, in particular, the development of practical skills. Objective reasons and
Timofeev, E.V., Olifirenko, I.S., Padorina, E.V., Yakovlev, Y.M., Sukhanov, D.S.   +4 more
doaj   +1 more source

Capturing Dynamics in Business Model Frameworks

Journal of Open Innovation: Technology, Market and Complexity, 2019
Business model dynamics is important, because high-tech companies, the technology that they commercialize, and the market in which they operate all change over time.
Hanieh Khodaei, Roland Ortt
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oficiales de la pluma y prácticas documentales en la Casa de la Contratación de Indias: su significación como instrumentos de gobierno

Nuevo mundo - Mundos Nuevos, 2017
The aim of this paper is to show an innovative view on the House of Trade as an organism producing documents for the government of America. One of the least known aspects of this institution is its internal functioning relating to the management and ...
Francisco Fernández-López
doaj   +1 more source

The influence of transitional and structural reforms on internal legitimacy and the structure of values [PDF]

Međunarodni Problemi, 2010
The paper explores the view of political transitions from the standpoint of capacity for collective action, and seeks to use a causal analysis of the motivation for collective action and its public articulation as a method of interpreting modern ...
Fatić Aleksandar
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Моделі управління регіональними освітніми мережами та комплексами [PDF]

, 2008
В роботі розглянуто формальний опис освітніх мереж та комплексів, який включає їх структурний та функціональний опис, розглянуто зовнішню, внутрішню та загальну моделі елементу регіональної освітньої мережі. Детально розглянуто потокову модель управління
Січко, Т. В.
core   +1 more source