Results 31 to 40 of about 822,379 (296)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Experimental Investigation of the Transient Flow in Roots Blower [PDF]
, 2018 Rotary positive displacement machines are common method to pump flow in various process industries. Their performance highly depends on the operational clearances.
Bruecker, C. +6 more
core +1 more source
Quantitative study of laterally inhomogeneous wetting films
, 1998 Based on a microscopic density functional theory we calculate the internal structure of the three-phase contact line between liquid, vapor, and a confining wall as well as the morphology of liquid wetting films on a substrate exhibiting a chemical step ...
C. Bauer +2 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Heterogeneous effects of climate change on displacement-inducing disasters
Frontiers in ClimateWith an estimated 357.7 million internal displacements caused since 2008, weather-related disasters are a major driver of human mobility worldwide. As climate change is projected to increase the frequency and intensity of extreme weather events in many ...
Robert Beyer +4 more
doaj +1 more source
Internal displacement in eastern Burma [PDF]
Forced Migration Review, 2007 The history of post-independent Burma is characterisedby numerous conflicts in this extraordinarily heterogeneous country. Since military rule began in 196 2 Burmahas witnessed gross human rights abuses andmassive displacement.
Heather Rae
doaj
Buildings, 2023 Viscoelastic dampers are conventional passive vibration control devices with excellent energy dissipation performance. The fractional derivative has a simple form and high accuracy in the modelling of viscoelastic materials/dampers.
Yeshou Xu +6 more
doaj +1 more source
Victims to villains: Internal displacement and nation-building in Ukraine [PDF]
, 2017 The war in Donbas has created large-scale displacement within Ukraine, an issue the impoverished state has struggled to manage. Internally displaced people (IDPs) have suffered from prejudice at the hands of host communities and from legal ambiguities ...
Rimpiläinen, Emma
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2019 Bimetallic catalysts can undergo segregation or redistribution of the metals driven by oxidizing and reducing environments. Bragg coherent diffraction imaging (BCDI) was used to relate displacement fields to compositional distributions in crystalline Pt ...
Cha, Wonsuk +13 more
core +1 more source