Results 51 to 60 of about 3,034,846 (297)

Modelling displacement

open access: yesForced Migration Review, 2015
Although those seeking a single global prediction will be disappointed, today’s models of climate change- and disaster-induced displacement can provide a range of scenarios for specific countries, regions or hotspots.
Justin Ginnetti
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Criminal violence and displacement in Mexico

open access: yesForced Migration Review, 2014
Rampant criminal violence, from direct coercion and physical threats to the erosion of the quality of life and livelihood opportunities, pushes people to move in a variety of ways. Not everyone forced to move has equal access to protection or asylum.
Sebastián Albuja
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The compound effects of conflict and disaster displacement in Bosnia and Herzegovina

open access: yesForced Migration Review, 2015
Some IDPs living in protracted displacement in Bosnia and Herzegovina, such as many Roma IDPs, were especially vulnerable to the effects of the May 2014 flooding and landslides.
Wesli H Turner
doaj  

The Guiding Principles on Internal Displacement: a new instrument for international organisations and NGOs [PDF]

open access: yesForced Migration Review, 1998
International organisations and NGOs have an important new document to turn to when they advocate on behalf of internally displaced populations: the Guiding Principles on Internal Displacement.
Roberta Cohen
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The importance of monitoring internal displacement

open access: yesForced Migration Review, 2018
The 2030 Agenda for Sustainable Development acknowledges the link between internal displacement and development, and States should therefore be including internal displacement when monitoring progress towards their development goals.
Christelle Cazabat
doaj  

Internal displacement and peacebuilding in Colombia [PDF]

open access: yesForced Migration Review, 2009
The advances in laws related to IDPs have not addressed the relationship between internal displacement and peacebuilding in Colombia.
Elizabeth Ferris
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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