Results 51 to 60 of about 206,952 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Internal displacement and peacebuilding in Colombia [PDF]

Forced Migration Review, 2009
The advances in laws related to IDPs have not addressed the relationship between internal displacement and peacebuilding in Colombia.
Elizabeth Ferris
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improving Kenya’s response to internal displacement [PDF]

Forced Migration Review, 2008
Over 300,000 Kenyans were displaced by post-electionconflict between December 2007 and January 2008. Kenyaneeds a coherent policy and capacity building for addressinginternal displacement.
Alex Otieno
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Guiding principles on internal displacement in the system of international protection of the internally displaced persons’ rights

Uzhhorod National University Herald. Series: Law
The article under studies carries out a complex analysis of the Guiding Principles on the issues of internal displacement as a universal international standard of the internally displaced persons’ rights. It points out that in terms of the rapid growth of internal displacement (caused by armed conflicts, political instability, massive violations of ...
T.A. Hrekul-Kovalyk, I.Zh. Toronchuk
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Internal displacement and the Kampala Convention: an opportunity for development actors [PDF]

, 2013
According to the African Union (AU), Africa is "a continent disproportionately affected by internal displacement". The African region, with almost 10 million people internally displaced in 22 countries by armed conflict and other forms of ...
Schrepfer, Nina, Kälin, Walter
core  

Shakedown and limit analysis of 90° pipe bends under internal pressure, cyclic in-plane bending and cyclic thermal loading [PDF]

, 2011
The Linear Matching Method is used to create the shakedown limit and limit load interaction curves of 90 degree pipe bends for a range of bend factors.
Ure, James Michael, James Ure, Haofeng Chen, Donald Mackenzie, Chen, Haofeng, Li, Tianbai, Tianbai Li, Mackenzie, Donald, Weihang Chen, Chen, Weihang   +9 more
core   +1 more source