Results 51 to 60 of about 822,379 (296)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Modelling displacement

open access: yesForced Migration Review, 2015
Although those seeking a single global prediction will be disappointed, today’s models of climate change- and disaster-induced displacement can provide a range of scenarios for specific countries, regions or hotspots.
Justin Ginnetti
doaj  

The role of GPR techniques in determining ice cave properties: Peña Castil ice cave, Picos de Europa [PDF]

open access: yes, 2016
Producción CientíficaThe structure and ice content of ice caves are poorly understood. Ground penetrating radar (GPR) can provide useful insights but has only rarely been applied to ice caves.
Gómez Lende, Manuel   +3 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Criminal violence and displacement in Mexico

open access: yesForced Migration Review, 2014
Rampant criminal violence, from direct coercion and physical threats to the erosion of the quality of life and livelihood opportunities, pushes people to move in a variety of ways. Not everyone forced to move has equal access to protection or asylum.
Sebastián Albuja
doaj  

Numerical simulation of ratcheting and fatigue behaviour of mitred pipe bends under in-plane bending and internal pressure [PDF]

open access: yes, 2013
This paper investigates the ratcheting and fatigue behaviour of 90 degree single unreinforced mitred pipe bends subjected to a cyclic in-plane closing moment with a non-zero mean value and constant internal pressure. An experiment was conducted to induce
Hamilton, Robert   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The compound effects of conflict and disaster displacement in Bosnia and Herzegovina

open access: yesForced Migration Review, 2015
Some IDPs living in protracted displacement in Bosnia and Herzegovina, such as many Roma IDPs, were especially vulnerable to the effects of the May 2014 flooding and landslides.
Wesli H Turner
doaj  

The Guiding Principles on Internal Displacement: a new instrument for international organisations and NGOs [PDF]

open access: yesForced Migration Review, 1998
International organisations and NGOs have an important new document to turn to when they advocate on behalf of internally displaced populations: the Guiding Principles on Internal Displacement.
Roberta Cohen
doaj  

Microtubule dynamics depart from wormlike chain model [PDF]

open access: yes, 2007
Thermal shape fluctuations of grafted microtubules were studied using high resolution particle tracking of attached fluorescent beads. First mode relaxation times were extracted from the mean square displacement in the transverse coordinate.
Ernst-Ludwig Florin   +5 more
core   +2 more sources

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