Results 61 to 70 of about 822,379 (296)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The importance of monitoring internal displacement
Forced Migration Review, 2018 The 2030 Agenda for Sustainable Development acknowledges the link between internal displacement and development, and States should therefore be including internal displacement when monitoring progress towards their development goals.
Christelle Cazabat
doaj
Internal displacement and peacebuilding in Colombia [PDF]
Forced Migration Review, 2009 The advances in laws related to IDPs have not addressed the relationship between internal displacement and peacebuilding in Colombia.
Elizabeth Ferris
doaj
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Improving Kenya’s response to internal displacement [PDF]
Forced Migration Review, 2008 Over 300,000 Kenyans were displaced by post-electionconflict between December 2007 and January 2008. Kenyaneeds a coherent policy and capacity building for addressinginternal displacement.
Alex Otieno
doaj
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Addressing Internal Displacement through National Laws and Policies: A Plea for a Promising Means of Protection [PDF]
, 2017 Unlike in the case of refugees, there is neither an international convention nor a dedicated UN agency in place to protect internally displaced persons.
Schrepfer, Nina
core
Anticipatory Effects on Lower Extremity Neuromechanics During a Cutting Task [PDF]
, 2015 Context: Continued research into the mechanism of noncontact anterior cruciate ligament injury helps to improve clinical interventions and injury-prevention strategies.
Geiser, Christopher +3 more
core +2 more sources
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source