Results 91 to 100 of about 507,672 (308)

Engineering failure analysis and design optimisation with HiP-HOPS [PDF]

, 2010
The scale and complexity of computer-based safety critical systems, like those used in the transport and manufacturing industries, pose significant challenges for failure analysis. Over the last decade, research has focused on automating this task.
Grätz, Uwe, Hamann, Rainer, Lien, Rune, Papadopoulos, Yiannis, Parker, David, Rüde, Erich, Uhlig, Andreas, Walker, Martin   +7 more
core   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Why the EU is failing in its neighbourhood: the case of Armenia [PDF]

, 2012
As the Arab Spring has made clear, the EU’s strategic aim of being surrounded by a ring of secure, democratic, and prosperous friends has not yet materialized. While most previous analyses have found fault with inconsistent application of conditionality,
Van Hoof, Lieve
core   +1 more source

Evidence of Quaternary tectonics along Río Grande valley, southern Malargüe fold and thrust belt, Mendoza, Argentina [PDF]

, 2019
The Malargüe fold and thrust belt is developed in the Argentinian Andes between 34° and 37° S, through the tectonic inversion of Upper Triassic and Lower Jurassic depocenters of the Neuquén Basin, with an uplift history since the Cretaceous.
Colavitto, Bruno, Costa, Carlos, Fennell, Lucas Martín, Folguera Telichevsky, Andres, Sagripanti, Lucía   +4 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

PHASE ANGLE SHIFT AND SLOPE BASED RESTRAINT FOR INDIRECT SYMMETRICAL PHASE SHIFT TRANSFORMER PROTECTION

Journal of Engineering and Sustainable Development
This study presents a method to limit the functioning of the differential relay during the different operating conditions of an Indirect Symmetrical Phase Shift Transformer (ISPST).
Shailendra Kumar Bhasker, Manoj Tripathy
doaj   +1 more source

Empirical evaluation of accuracy of mathematical software used for availability assessment of fault-tolerant computer systems [PDF]

, 2012
Dependability assessment is typically based on complex probabilistic models. Markov and semi-Markov models are widely used to model dependability of complex hardware/software architectures.
Kharchenko, V. S., Odarushchenko, O., Popov, P. T., Zhadan, V.   +3 more
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source