Results 61 to 70 of about 484,641 (333)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Charnley-Hastings hemiartoplastikk ved disloserte lårhalsbrudd. En sammenlikning av primær hemiprotese versus hemiprotese sekundært til havarert skruefiksasjon. : en prospektiv registrering av 524 pasienter med lårhalsbrudd [PDF]

, 2005
Treatment of Displaced Intracapsular Hip Fractures with Charnley Hastings hemi-arthroplasty: Comparison of Primary hemi-arthroplasty with Early Salvage hemi-arthroplasty After Failed Internal Fixation Heidi Nygaard Bakken and Torbjørn Mæhlum Ullevål ...
Bakken, Heidi Nygaard, Mæhlum, Torbjørn   +1 more
core  

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Risk of internal fixation treatment in intertrochanteric fracture based on different lateral femoral wall thickness: finite element analysis

BMC Musculoskeletal Disorders
Objective The thickness of the lateral femoral wall, which is an important indicator for evaluating the stability and integrity of intertrochanteric fractures, has been widely studied in recent years.
Xu Zhang, Yazhong Zhang, Xiangyu Qi, Shaolong Huang, Yongxiang Lv, Wenbo Li, Chao Li, Ziqiang Zhu   +7 more
doaj   +1 more source

Cost Comparison and Complication Rate of Lisfranc Injuries Treated with Open Reduction Internal Fixation versus Primary Arthrodesis

Foot & Ankle Orthopaedics, 2018
Category: Midfoot/Forefoot Introduction/Purpose: Controversy exists regarding optimal primary management of Lisfranc injuries. Whether open reduction internal fixation or primary arthrodesis is superior remains unknown.
Brandon Barnds MD, Bryan Vopat MD, Scott Mullen MD, Paul Schroeppel MD, Brandon Morris MD, Armin Tarakemeh BA   +5 more
doaj   +1 more source

Assesment [sic] of cement augmentation and screw trajectory on pedicle screw fixation in osteoporotic vertebrae [PDF]

, 2010
Internal fixation of osteoporotic spines for fracture or deformity is currently difficult, owing to failure at the bone- implant interface. This study aims to ascertain whether pedicle screw trajectory and pedicle cortex retention can independently ...
Hirner, Jesse, Pfeiffer, Ferris M., 1976-   +1 more
core  

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Conscious Processing During Retrieval Can Occur in Early and Late Visual Regions [PDF]

, 2013
Previous evidence has suggested a functional-anatomic dissociation between conscious and nonconscious processing during retrieval where early visual regions BA17/18 are associated with nonconscious processing and late visual regions BA19/37 are ...
Schacter, Daniel L., Slotnick, Scott D., Thakral, Preston P.   +2 more
core   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source