Results 91 to 100 of about 2,310,959 (353)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The influence of the European Union on combating irregular migration in the Republic of Serbia [PDF]

Politika nacionalne bezbednosti
The European Union has been leading a common policy in combating irregular migration for many years. It is based on the comprehensive cooperation of all actors involved in population migration and, above all, with the countries of origin, transition and ...
Cvetković Nenad, Obradović Zoran
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Internal centralization and international integration in the post-Soviet space [PDF]

An important but often neglected factor influencing the changes in power relations in Eurasia is the development of center-periphery relations in individual countries.
Libman, Alexander
core   +1 more source

Modeling the Effects of Interrelations Among External Support and Internal Factors on Teachers’ ICT Integration Ability in Less Developed Areas of China

SAGE Open
The research exploring the cumulative impact of influencing factors on teachers’ ICT integration ability is lacking. Additionally, the mediating role of internal factors on the relationship between external support and teachers’ ICT integration ability ...
Shun Xu, Tiehao Zhao, Zhongmei Zheng, Sha Zhu   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

MULTI LEVEL MARKETING INTEGRATION PROCESS MANAGEMENT [PDF]

The paper’s intention is to deal with the issues of the comprehensive multu level marketing integration. It is a conceptual view over the different aspect of the integration process on different levels.
Nicola Yankov
core  

Supply chain integration in the product return process: A study of consumer electronics retailers

Acta Commercii, 2017
Background: The increasing complexity and levels of competition facing firms have reiterated the need to integrate the flow of goods and information within and between firms. Limited research has, however, been done regarding this integration in terms of
Wynand Mostert, Wesley Niemann, Theuns Kotzé   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Logistics integration processes in the food industry [PDF]

This paper analyses the integration process that firms follow to implement Supply Chain Management (SCM). This study has been inspired in the integration model proposed by Stevens (1989).
Cristina Giménez
core