Results 31 to 40 of about 3,490,356 (314)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management [PDF]

, 2021
The incidence and prevalence rates of inf lammatory bowel disease (IBD) have been increasing in East Asian countries over the past few decades. Accordingly, the general understanding and awareness of IBD among healthcare professionals has increased ...
천재희, 박지혜
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia [PDF]

, 2016
BACKGROUND: Patients with non-transfusion-dependent thalassemia (NTDT) present with a spectrum of disease severities. Since there are multiple pathophysiologies in such patients, tailoring treatment remains essential. Therefore, one simple, reliable tool
Porter, John B., Kattamis, Antonis C., Cappellini, Maria Teresa, Musallam, Khaled M., Galanello, Renzo, Taher, Ali T., Viprakasit, Vip   +6 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Internal Medicine Residents’ Perceptions of Point-of-Care Ultrasound in Residency Program: Highlighting the Unmet Needs [PDF]

, 2021
Background: Point-of-care ultrasound (POCUS) is increasingly used in internal medicine   field. Ultrasound training has been part of the training provided in the Internal Medicine Residency Program (IMRP).
Rabbinu Rangga Pribadi, Pribadi, Rabbinu Rangga, Martha Rosana, Harimurti, Kuntjoro, Asmara, Oke Dimas, Kemal Fariz Kalista, Rosana, Martha, Oke Dimas Asmara, Kalista, Kemal Fariz, Kuntjoro Harimurti   +9 more
core  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Political issues in internal medicine in Europe. A position paper.

, 2005
What will be the future of internal medicine in Europe? Because of rapidly growing concerns regarding the position of internal medicine in many European countries, the European Federation of Internal Medicine (EFIM) has established a working group to ...
KRAMER M, SCHUMM DRAEGER PM, HIGGENS C, UNAL S., FERREIRA F, KOEBBERLING J, MITTELMAN M, LICATA, Giuseppe, O'HARE J, GARCIA ALEGRIA JJ, BAUER W, GJOERUP T   +11 more
core   +1 more source

Role of C-Reactive Protein and Procalcitonin in Differentiation of Tuberculosis from Bacterial Community Acquired Pneumonia. [PDF]

, 2009
BACKGROUND/AIMS: We investigated the utility of serum C-reactive protein (CRP) and procalcitonin (PCT) for differentiating pulmonary tuberculosis (TB) from bacterial community-acquired pneumonia (CAP) in South Korea, a country with an intermediate TB ...
강영애
core   +1 more source