Results 41 to 50 of about 3,464,303 (269)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Long-Term Trends in Sepsis Mortality Among Older U.S. Adults with Chronic Kidney Disease, 1999–2023

ASIDE Internal Medicine
Background: Sepsis causes 1 in 3 U.S. hospital deaths, especially deadly among adults ≥65 with CKD, affecting over 30% of over-70s. Long-term trends in this group are understudied.
Umar Aziz, Roshni Riaz Memon, Muhammad Mussawir Khuhro, Huda Ahmed, Sarah Azhar, Hamama Waseem, Maryam Waqar, Muhammad Waaiz, Mominah Majid, Raveen Mujeeb   +9 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Periprosthetic Joint Infection in Egypt: A Narrative Review of the Current Landscape and Knowledge Gaps

ASIDE Internal Medicine
Background: Periprosthetic joint infection (PJI) is one of the most serious complications of total joint arthroplasty (TJA). This review synthesizes the available local evidence of PJI in Egypt to identify the current landscape and knowledge gaps in the
Asem Mohsen, Mostafa Alfishawy
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Psychological Burden in Behçet Disease: A Narrative Review Across Mucocutaneous, Articular, and Ocular Manifestations

ASIDE Internal Medicine
Background: Behçet disease is a chronic, relapsing, multisystem inflammatory vasculitis in which mucocutaneous, articular, and ocular manifestations may coexist with substantial psychological burden.
Ahmed Ismael, Ahmed Mabrouk, Mahmoud Zeinhom Ramadan, Hussein Eldamery, Assem Amer, Mohamed Fouad M Ragab, Sherif Helal, Elsadek Helal E. Mahdi, Sherin A Ghaith, Mahmoud M Saber Abdelwahed, Mohammad M. Badran, Ashraf E.M. Ebaid   +11 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Efficacy and Safety of Penehyclidine Hydrochloride in Postoperative Nausea and Vomiting Prevention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

ASIDE Internal Medicine
Introduction: Postoperative nausea and vomiting (PONV) is a common complication following anesthesia. Penehyclidine hydrochloride (PHC), an anticholinergic medication, selectively inhibits the M1 Muscarinic and M3 Muscarinic receptors involved in the ...
Ahmed Magdy, Eithar Alqady, Mohamed Wagdy, Ahmed T.shalby, Mahmoud Abdelkader, Karim Osamy, Alaa Anter, IhabTarik, Manar Samy, Sherif Eltawansy, Ahmed Hassan   +10 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Antibiotic Knowledge, Perception, and Practice of Intern Doctors in Turkey:  A Survey Study

ASIDE Internal Medicine
Background: This study aimed to measure intern doctors' knowledge, attitudes, and perceptions about antibiotic treatment and determine the situation on the subject.
AHMET DOĞAN, Azra SÖNMEZ, Beyza DİŞLİ, Hasan Şamil ÇELİK, Chingiz RUSTAMLİ, Ecem Berra NAZLIOĞLU, Zuhat ABDULKERİMOĞLU, Mustafa Talha ALTUNBAŞ, Rumeysa ÖZER   +8 more
doaj   +1 more source